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Symptom-associated Change of Motor-Related Neuromagnetic Fields in a Patient With Multiple Sclerosis: A Case Report

Authors
 Ji Hee Kim  ;  Bong Soo Kim  ;  Su Jeong Hwang  ;  Won Seok Chang  ;  Ki Woong Kim  ;  Hyuk Chan Kwon  ;  Yong Ho Lee  ;  Jin Woo Chang 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.50 : 115-122, 2018-04 
Journal Title
 JOURNAL OF CLINICAL NEUROSCIENCE 
ISSN
 0967-5868 
Issue Date
2018-04
MeSH
Brain Mapping / methods ; Evoked Potentials, Motor / physiology ; Female ; Humans ; Magnetoencephalography / methods* ; Middle Aged ; Motor Cortex / diagnostic imaging* ; Motor Cortex / physiopathology* ; Movement / physiology ; Multiple Sclerosis / diagnostic imaging* ; Multiple Sclerosis / physiopathology*
Keywords
Demyelinating disease ; Demyelination ; Magnetoencephalography ; Multiple sclerosis ; Neuromagnetic field
Abstract
The objective of this study was to investigate functional abnormalities of the brain in a patient with multiple sclerosis (MS) by using magnetoencephalography (MEG) and a finger-tapping task. A 46-year-old woman that presented with motor weakness of left hand and was diagnosed with MS. Conventional magnetic resonance imaging demonstrated a white matter lesion with hyperintensity on T2-weighted images in the right motor area. MEG recordings were performed during the period of motor weakness and after clinical improvement. Neuromagnetic brain activation was elicited by a simple, visually cued finger movement. The Equivalent current dipole (ECD) strength of the movement-evoked field (MEF) in the affected hemisphere was significantly decreased relative to the unaffected hemisphere. After improvement in motor weakness, we found that the lower amplitude of the readiness field and decreased ECD strength of the MEF observed in affected hemisphere during motor weakness had recovered. Analysis of motor-related neuromagnetic fields revealed that MEG may be used to detect diffuse changes in the brain that are not observable by conventional imaging of white matter regions in MS. We further found that brain activities can change after improvement in motor weakness.
Full Text
https://www.sciencedirect.com/science/article/pii/S0967586817320210
DOI
10.1016/j.jocn.2018.01.060
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175843
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