Cited 27 times in

Impact of miR-192 and miR-194 on Cyst Enlargement Through EMT in Autosomal Dominant Polycystic Kidney Disease

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dc.contributor.author복진웅-
dc.contributor.author신정오-
dc.date.accessioned2020-06-04T08:38:49Z-
dc.date.available2020-06-04T08:38:49Z-
dc.date.issued2019-02-
dc.identifier.issn0892-6638-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175827-
dc.description.abstractAltered miRNA (miR) expression occurs in various diseases. However, the therapeutic effect of miRNAs in autosomal dominant polycystic kidney disease (ADPKD) is unclear. Genome-wide analyses of miRNA expression and DNA methylation status were conducted to identify crucial miRNAs in end-stage ADPKD. miR-192 and -194 levels were down-regulated with hypermethylation at these loci, mainly in the intermediate and late stages, not in the early stage, of cystogenesis, suggesting their potential impact on cyst expansion. Cyst expansion has been strongly associated with endothelial-mesenchymal transition (EMT). Zinc finger E-box-binding homeobox-2 and cadherin-2, which are involved in EMT, were directly regulated by miR-192 and -194. The therapeutic effect of miR-192 and -194 in vivo and in vitro were assessed. Restoring these miRs by injection of precursors influenced the reduced size of cysts in Pkd1 conditional knockout mice. miR-192 and -194 may act as potential therapeutic targets to control the expansion and progression of cysts in patients with ADPKD.-Kim, D. Y., Woo, Y. M., Lee, S., Oh, S., Shin, Y., Shin, J.-O., Park, E. Y., Ko, J. Y., Lee, E. J., Bok, J., Yoo, K. H., Park, J. H. Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherThe Federation-
dc.relation.isPartOfFASEB JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, CD / genetics-
dc.subject.MESHAntigens, CD / metabolism-
dc.subject.MESHCadherins / genetics-
dc.subject.MESHCadherins / metabolism-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDNA Methylation-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEpithelial-Mesenchymal Transition*-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHGene Expression Regulation*-
dc.subject.MESHGenome-Wide Association Study-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMicroRNAs / genetics*-
dc.subject.MESHPolycystic Kidney, Autosomal Dominant / genetics-
dc.subject.MESHPolycystic Kidney, Autosomal Dominant / metabolism-
dc.subject.MESHPolycystic Kidney, Autosomal Dominant / pathology*-
dc.subject.MESHProtein-Serine-Threonine Kinases / physiology*-
dc.subject.MESHPyruvate Dehydrogenase (Acetyl-Transferring) Kinase-
dc.subject.MESHZinc Finger E-box Binding Homeobox 2 / genetics-
dc.subject.MESHZinc Finger E-box Binding Homeobox 2 / metabolism-
dc.titleImpact of miR-192 and miR-194 on Cyst Enlargement Through EMT in Autosomal Dominant Polycystic Kidney Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorDo Yeon Kim-
dc.contributor.googleauthorYu Mi Woo-
dc.contributor.googleauthorSunyoung Lee-
dc.contributor.googleauthorSumin Oh-
dc.contributor.googleauthorYubin Shin-
dc.contributor.googleauthorJeong-Oh Shin-
dc.contributor.googleauthorEun Young Park-
dc.contributor.googleauthorJe Yeong Ko-
dc.contributor.googleauthorEun Ji Lee-
dc.contributor.googleauthorJinwoong Bok-
dc.contributor.googleauthorKyung Hyun Yoo-
dc.contributor.googleauthorJong Hoon Park-
dc.identifier.doi10.1096/fj.201800563RR-
dc.contributor.localIdA01865-
dc.contributor.localIdA02148-
dc.relation.journalcodeJ00889-
dc.identifier.eissn1530-6860-
dc.identifier.pmid30332302-
dc.identifier.urlhttps://www.fasebj.org/doi/full/10.1096/fj.201800563RR-
dc.subject.keywordADPKD-
dc.subject.keywordDNA methylation-
dc.subject.keywordN-cadherin-
dc.subject.keywordZEB2-
dc.subject.keywordmicroRNA-
dc.contributor.alternativeNameBok, Jin Woong-
dc.contributor.affiliatedAuthor복진웅-
dc.contributor.affiliatedAuthor신정오-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage2870-
dc.citation.endPage2884-
dc.identifier.bibliographicCitationFASEB JOURNAL, Vol.33(2) : 2870-2884, 2019-02-
dc.identifier.rimsid64454-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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