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Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs

Authors
 Younhee Ko  ;  Chulho Lee  ;  Youngmok Lee  ;  Jin-Sung Lee 
Citation
 DIAGNOSTICS, Vol.9(4) : 208, 2019-12 
Journal Title
 DIAGNOSTICS 
Issue Date
2019-12
Keywords
NGS ; drug repositioning ; drug-target network ; epilepsy ; precise medicine
Abstract
Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug-target network (EDT) is constructed and successfully demonstrates the characteristics and efficacy of popularly used AEDs through the identification of causative genes for 60 epilepsy patients. We discovered that the causative genes of most intractable patients were not the targets of existing AEDs, as well as being very far from the etiological mechanisms of existing AEDs in the functional networks. We show that the existence of new drugs that target the causative genes of intractable epilepsy patients, which will be potential candidates for refractory epilepsy patients. Our systematic approach demonstrates a new possibility for drug repositioning through the combination of the drug-target and functional networks.
Files in This Item:
T201906328.pdf Download
DOI
10.3390/diagnostics9040208
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Young Mock(이영목) ORCID logo https://orcid.org/0000-0002-5838-249X
Lee, Jin-Sung(이진성) ORCID logo https://orcid.org/0000-0002-1262-8597
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175822
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