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Usefulness of the Psoriatic Arthritis Screening and Evaluation Questionnaire to Monitor Disease Activity in Management of Patients with Psoriasis: Findings from the EPI-PSODE Study

 Yong Beom Choe  ;  Chul Jong Park  ;  Dae Young Yu  ;  Youngdoe Kim  ;  Hyun Jeong Ju  ;  Sang Woong Youn  ;  Joo-Heung Lee  ;  Byung Soo Kim  ;  Seong Jun Seo  ;  Seok-Kweon Yun  ;  Joonsoo Park  ;  Nack In Kim  ;  Jai Il Youn  ;  Seok-Jong Lee  ;  Min-Geol Lee  ;  Kwang Joong Kim  ;  Young Suck Ro  ;  Hae Jun Song  ;  Bong Seok Shin  ;  Sung Ku Ahn  ;  Ji Yeoun Lee  ;  Young Ho Won  ;  Min Soo Jang  ;  Ki Ho Kim  ;  Myung Hwa Kim  ;  Tae Yoon Kim  ;  Jee-Ho Choi 
 ANNALS OF DERMATOLOGY, Vol.31(1) : 29-36, 2019-02 
Journal Title
Issue Date
Arthritis ; Psoriatic
Background Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring inflammatory activity in patients with psoriasis, such as the Psoriasis Area and Severity Index (PASI), are limited. Objective To determine whether the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire can be used to monitor disease activity in patients with psoriasis. Methods This was a multicenter, noninterventional, cross-sectional study. Demographic factors and PASI and PASE scores were collected to investigate associations between each. Results PASE data were available for 1,255 patients, of whom 498 (39.7%) had a score of ≥37. Compared with the group with PASE score <37, the group with score ≥37 had a higher proportion of women (34.9% vs. 48.8%, p<0.0001), older mean age at diagnosis (36.4 vs. 41.7 years, p<0.0001), more severe disease activity using PASI and body surface area measures (p=0.0021 and p=0.0008, respectively), and higher mean body mass index (23.7 vs. 24.1, p=0.0411). In a multiple linear regression model, PASE score was positively associated with cutaneous disease activity (p<0.0001). Conclusion After risk-adjustment, PASE was positively associated with PASI, which suggests that PASE can be sensitive to disease activity. Since psoriasis is regarded as one of the IMIDs, PASE may be utilized as a tool not only to screen PsA but also to monitor disease activity.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
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