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Left Ventricular Global Longitudinal Strain as a Predictor for Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy

Authors
 In Hyun Jung  ;  Jin Hye Park  ;  Jeong-A Lee  ;  Gwang Sil Kim  ;  Hye Young Lee  ;  Young Sup Byun  ;  Byung Ok Kim 
Citation
 J Cardiovasc Imaging, Vol.28(2) : 137-149, 2020 
Journal Title
 J Cardiovasc Imaging 
Issue Date
2020
Keywords
Dilated cardiomyopathy ; Echocardiography ; Strain ; Left ventricle
Abstract
BACKGROUND A considerable number of patients with dilated cardiomyopathy (DCM) experience left ventricular reverse remodeling (LVRR). LV global longitudinal strain (LV GLS) offers sensitive and reproducible measurement of myocardial dysfunction. The authors sought to evaluate whether LV GLS at the time of diagnosis may predict LVRR in DCM patients with sinus rhythm and investigate its prognostic role in long-term follow-up in this population. METHODS We enrolled 160 DCM patients with sinus rhythm who had been initially diagnosed, evaluated, and followed at our institute. We analyzed their medical records and echocardiographic data. RESULTS During the mean follow-up duration of 37.3 ± 21.7 months, LVRR occurred in 28% of patients (n = 45). The initial LV ejection fraction (LVEF) of patients who recovered LV function was 26.1 ± 7.9%, which was not significantly different from the value of 27.1 ± 7.4% (p = 0.49) in those who did not recover. There was a moderate and highly significant correlation between baseline LV GLS (−%) and follow-up LVEF (r = 0.717; p < 0.001). Using multivariate Cox analysis, LV GLS (hazard ratio: 1.474, 95% confidence interval: 1.170-1.856; p = 0.001) was an independent predictor of LVRR. CONCLUSIONS We demonstrated that LV GLS was an independent predictor for LVRR and the optimal cut-off point of LV GLS for LVRR was −10% in DCM patients with sinus rhythm. There was a significant correlation between baseline LV GLS and follow-up LVEF.
Files in This Item:
T999202012.pdf Download
DOI
10.4250/jcvi.2019.0111
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jung, In Hyun(정인현) ORCID logo https://orcid.org/0000-0002-1793-215X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175761
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