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First Detection of New Delhi Metallo-β-Lactamase-5-Producing Escherichia coli from Companion Animals in Korea

Authors
 Jun Sung Hong  ;  Wonkeun Song  ;  Hee-Myung Park  ;  Jae-Young Oh  ;  Jong-Chan Chae  ;  Jae-Ik Han  ;  Seok Hoon Jeong 
Citation
 Microbial Drug Resistance, Vol.25(3) : 344-349, 2019 
Journal Title
 Microbial Drug Resistance 
ISSN
 1076-6294 
Issue Date
2019
MeSH
Animals ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/genetics ; Escherichia coli/drug effects ; Escherichia coli/genetics* ; Escherichia coli/isolation & purification* ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Humans ; Microbial Sensitivity Tests/methods ; Pets/microbiology* ; Plasmids/genetics ; Republic of Korea ; beta-Lactamases/genetics*
Keywords
IncX3 plasmid ; NDM-5 ; companion animal
Abstract
The gene for New Delhi metallo-β-lactamase-5 (NDM-5) in Escherichia coli has been identified in many countries mainly from human clinical specimens. The isolates carrying this gene are even more rarely isolated from companion animals. In this study, four carbapenem-resistant isolates were recovered from four dogs in Korea. All isolates carried blaNDM-5 and exhibited resistance to meropenem and imipenem, and were susceptible to colistin. Epidemiological analysis showed that all four isolates were sequence type 410 (ST410) and shared 99% similarity as determined by pulsed-field gel electrophoresis analysis. Among the four isolates, the Z0117EC0033 strain was randomly selected for whole-genome sequencing, composed of a 4.7Mb circularized chromosome carrying the CMY-2 gene and two plasmids. The first plasmid of the IncFIB type had 83 coding sequences (CDS) in ca. 74 kb. The second smaller plasmid of the IncX3 type had 57 CDS and carried only the blaNDM-5 gene in ca. 46 kb. The plasmid structures were highly similar (> 99%) to those of the NDM-5 human-like IncX3 plasmid. This is the first report of carbapenemase-producing Enterobacteriaceae from companion animals in Korea. The human-like blaNDM-5 IncX3 plasmid identified in this study suggests a potential transmission route of the NDM-5 plasmid between humans and companion animals.
Full Text
https://www.liebertpub.com/doi/abs/10.1089/mdr.2018.0237
DOI
10.1089/mdr.2018.0237
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Hong, Jun Sung(홍준성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175683
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