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Molecular Characteristics of GES-Type Carbapenemase-Producing Pseudomonas aeruginosa Clinical Isolates from Long-Term Care Facilities and General Hospitals in South Korea

Authors
 Jun Sung Hong  ;  Naeun Choi  ;  Si Jong Kim  ;  Kwang Hoo Choi  ;  Kyoung Ho Roh  ;  SunHwa Lee 
Citation
 Microbial Drug Resistance, : epub., 2019 
Journal Title
 Microbial Drug Resistance 
ISSN
 1076-6294 
Issue Date
2019
Keywords
GES-24 ; GES-5 ; Pseudomonas aeruginosa ; carbapenemase ; genomic island
Abstract
Since carbapenems have been used for the treatment of infections in medical settings, multidrug-resistant Pseudomonas aeruginosa containing resistance for carbapenems has become a major cause of nosocomial infections worldwide. Information on carbapenemase-producing P. aeruginosa isolates at community hospitals, including long-term care facilities and general hospitals, has rarely been reported in South Korea. The aims of this study were to describe the characteristics of seven carbapenemase-producing P. aeruginosa isolates recovered from two long-term care facilities in South Korea. The carbapenemase genes were identified by PCR and sequencing. Strain typing was assessed by pulsed field gel electrophoresis and multilocus sequence typing (MLST) analysis. Isolates with a genomic island and class I integron surrounding blaGES-type were confirmed by the PCR mapping method. Of seven GES-type carbapenemase-producing P. aeruginosa isolates, the blaGES-24 gene was detected in six isolates, and the blaGES-5 gene was detected in one isolate. The epidemiological relatedness of the seven isolates carrying blaGES-24 and blaGES-5 showed >81% similarity. Five isolates carrying blaGES-24 were sequence type 155 (ST155) by MLST, followed by one ST244 isolate carrying blaGES-24 and one ST308 isolate carrying blaGES-5. blaGES-type genes were embedded in two different class I integrons in a genomic island-15-like region. Our results indicate the possible spread of carbapenemase-producing P. aeruginosa and present a current threat of antimicrobial resistance in community hospitals.
Full Text
https://www.liebertpub.com/doi/abs/10.1089/mdr.2019.0302
DOI
10.1089/mdr.2019.0302
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Hong, Jun Sung(홍준성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175682
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