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Comparison of Fever-reducing Effects in Self-reported Data from the Mobile App: Antipyretic Drugs in Pediatric Patients

 Jiyun Choi  ;  Seyun Chang  ;  Jong Gyun Ahn 
 SCIENTIFIC REPORTS, Vol.10(1) : e3879, 2020 
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We compared the fever-reducing efficacy of acetaminophen (AA), ibuprofen (IBU), and dexibuprofen (DEX) using data collected from the mobile healthcare application FeverCoach, which provides parents with guidelines for determining their child's health condition, according to body temperature. Its dataset includes 4.4 million body temperature measurement records and 1.6 million antipyretics treatment records. Changes in body temperature over time were compared after taking one of three different antipyretics (AA, IBU, and DEX), using a one-way ANOVA followed by a post-hoc analysis. A multivariate linear model was used to further analyze the average body temperature differences, calibrating for the influences of age, weight, and sex. Children administered IBU had average body temperatures that were 0.18 °C (0.17-0.19 °C), 0.25 °C (0.24-0.26 °C), and 0.18 °C (0.17-0.20 °C) lower than those of children administered AA, at time intervals of 1-2 hours, 2-3 hours, and 3-4 hours, respectively. Similarly, children administered DEX had average body temperatures that were 0.24 °C (0.24-0.25 °C), 0.28 °C (0.27-0.29 °C), and 0.12 °C (0.10-0.13 °C) lower than those of children administered AA, at time intervals of 1-2, 2-3, and 3-4 hours, respectively. Although the data were collected from the application by non-professional parents, the analysis showed that IBU and DEX were more effective in reducing body temperature than AA was.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jong Gyun(안종균) ORCID logo https://orcid.org/0000-0001-5748-0015
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