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Age-Related Difference in the Effect of Acute Hyperglycemia on Myocardial Ischemia-Reperfusion Injury

Authors
 Sung Yeon Ham  ;  Sang Beom Nam  ;  Young-Lan Kwak  ;  Tae Lim Kim  ;  Jong-Kwang Park  ;  Yon Hee Shim 
Citation
 JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, Vol.75(3) : 425-431, 2020 
Journal Title
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN
 1079-5006 
Issue Date
2020
Keywords
Apoptosis ; Autophagy ; Myocardial infarction
Abstract
Age and acute hyperglycemia are known risk factors of myocardial ischemia-reperfusion injury. We investigated age-related difference in the effect of acute hyperglycemia on myocardial ischemia-reperfusion injury in Sprague-Dawley rats (young, 3 months; middle-aged, 10-12 months; and old, 22-24 months). The rats received 1.2 g/kg dextrose or normal saline and were subjected to coronary artery occlusion for 45 minutes followed by reperfusion for 240 minutes. Infarct size and ejection fraction were measured. The levels of apoptosis-related proteins (C-PARP, Bcl-2, Bax, and cytochrome c) and autophagy-related proteins (Bnip3, Beclin-1, Atg5, and LC3B-II) were evaluated. Infarct size increased with acute hyperglycemia in young and middle-aged rats but not in old rats, whereas the reduction of ejection fraction after ischemia-reperfusion was aggravated by acute hyperglycemia in all age groups. Acute hyperglycemia increased Bnip3 and Beclin-1 expressions after ischemia-reperfusion in young and middle-aged rats but not in old rats, whereas it increased the expression of Bax, cytochrome c, Atg5, and LC3B-II only in young or middle-aged rats. Conclusively, acute hyperglycemia does not aggravate myocardial ischemia-reperfusion injury in old rats, unlike in young and middle-aged rats. This heterogeneity may be due to attenuated changes in protein signaling after ischemia-reperfusion injury under acute hyperglycemia in old rats.
Full Text
https://academic.oup.com/biomedgerontology/article/75/3/425/5267850
DOI
10.1093/gerona/gly292
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Kim, Tae Lim(김태림) ORCID logo https://orcid.org/0000-0001-9421-7486
Nam, Sang Beom(남상범) ORCID logo https://orcid.org/0000-0002-9704-1866
Park, Jong-Kwang(박종광) ORCID logo https://orcid.org/0000-0002-7304-3509
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Ham, Sung Yeon(함성연) ORCID logo https://orcid.org/0000-0001-8619-4595
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175575
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