35 58

Cited 0 times in

Pulp-Dentin Tissue Healing Response: A Discussion of Current Biomedical Approaches

Authors
 Dishant Shah  ;  Tyler Lynd  ;  Donald Ho  ;  Jun Chen  ;  Jeremy Vines  ;  Hwi-Dong Jung  ;  Ji-Hun Kim  ;  Ping Zhang  ;  Hui Wu  ;  Ho-Wook Jun  ;  Kyounga Cheon 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.9(2) : E434, 2020 
Journal Title
 JOURNAL OF CLINICAL MEDICINE 
Issue Date
2020
Keywords
Biomaterials ; Chemical Signaling ; Immune Cells ; Inflammatory Response ; Mesenchymal Stem Cells ; Nitric Oxide ; Pulp–Dentin Tissue ; Tissue Regeneration
Abstract
Dental pulp tissue exposed to mechanical trauma or cariogenic process results in root canal and/or periapical infections, and conventionally treated with root canal procedures. The more recent regenerative endodontic procedure intends to achieve effective root canal disinfection and adequate pulp-dentin tissue regeneration; however, numerous limitations are reported. Because tooth is composed of vital soft pulp enclosed by the mineralized hard tissue in a highly organized structure, complete pulp-dentin tissue regeneration has been challenging to achieve. In consideration of the limitations and unique dental anatomy, it is important to understand the healing and repair processes through inflammatory-proliferative-remodeling phase transformations of pulp-dentin tissue. Upon cause by infectious and mechanical stimuli, the innate defense mechanism is initiated by resident pulp cells including immune cells through chemical signaling. After the expansion of infection and damage to resident pulp-dentin cells, consequent chemical signaling induces pluripotent mesenchymal stem cells (MSCs) to migrate to the injury site to perform the tissue regeneration process. Additionally, innovative biomaterials are necessary to facilitate the immune response and pulp-dentin tissue regeneration roles of MSCs. This review highlights current approaches of pulp-dentin tissue healing process and suggests potential biomedical perspective of the pulp-dentin tissue regeneration.
Files in This Item:
T202000627.pdf Download
DOI
10.3390/jcm9020434
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Hwi Dong(정휘동) ORCID logo https://orcid.org/0000-0003-1025-8323
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175542
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links