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Circulating myokine levels in different stages of glucose intolerance

 Kahui Park  ;  Chul Woo Ahn  ;  Jong Suk Park  ;  YuSik Kim  ;  Ji Sun Nam 
 MEDICINE, Vol.99(8) : e19235, 2020 
Journal Title
Issue Date
Adult ; Aged ; Chemokine CX3CL1/biosynthesis ; Cross-Sectional Studies ; Cytokines/biosynthesis* ; Diabetes Mellitus, Type 2/physiopathology* ; Female ; Fibronectins/biosynthesis* ; Follistatin-Related Proteins/biosynthesis* ; Glucose Intolerance/physiopathology ; Glycated Hemoglobin A ; Humans ; Male ; Middle Aged ; Prediabetic State/physiopathology* ; Prospective Studies ; Young Adult
Type 2 diabetes is the fastest growing metabolic disease in the world. Recently, muscle is considered an endocrine organ which secretes various peptides that play an important role in insulin resistance and metabolic syndrome. We assessed 4 different myokines, irisin, interleukin-13 (IL-13), follistatin-related protein-1 (FSTL-1), and fractalkine, in normal, prediabetes, and diabetes patients.A total of 126 participants who visited Gangnam Severance Hospital were enrolled and divided into normal, prediabetes, and diabetes groups based on oral glucose tolerance test and hemoglobin a1c. A cross-sectional study was conducted to measure and compare serum levels of irisin, IL-13, FSTL-1, and fractalkine among the groups.Irisin level showed a tendency to increase in prediabetes group compared to normal group (P < .1) but showed a significant decrease when comparing diabetes from prediabetes group (P < .001). IL-13 decreased in diabetes group compared to prediabetes and normal group (P < .001, P < .05, respectively). FSTL-1 of diabetes group was lower than that of prediabetes group (P < .05), and fractalkine was higher in diabetes group compared to that of prediabetes and normal group (P < .01, P < .01, respectively).Irisin, IL-13, and FSTL-1 levels were reduced in diabetes group compared to normal or prediabetes group while fractalkine showed a progressive increase from normal to diabetes group. Further studies are warranted to study the roles of various myokine in diabetes through a larger prospective study.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Kahui(박가희)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
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