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Quantitative Interpretation of Hydration Dynamics Enabled the Fabrication of a Zwitterionic Antifouling Surface

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dc.contributor.author권재성-
dc.contributor.author최성환-
dc.date.accessioned2020-04-13T16:47:52Z-
dc.date.available2020-04-13T16:47:52Z-
dc.date.issued2020-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175516-
dc.description.abstractIn the medical industry, zwitterionic brushes have received significant attention owing to their antifouling effect that arose from their hydration ability. However, sufficient understanding of the hydration dynamics of zwitterionic brushes is required to fabricate the precisely controlled antifouling medical devices. In this paper, we successfully show that hydration, the interaction between water molecules and zwitterionic brushes, and its dynamics can be evaluated logically and quantitatively using (i) water contact angle, (ii) molecular dynamics simulation, and (iii) Raman spectroscopy. Based on the intuitive results on hydration, we precisely optimized the antifouling property of the model medical device, a removable orthodontic retainer, with various grafting efficiencies of 2-methacryloyloxyethyl phosphate choline. As a result, the model device reduced nonspecific adsorption of proteins and bacteria, indicating an improved antifouling effect, and also inhibited the formation of a biofilm. Furthermore, the device showed excellent physical properties desirable for application in the orthodontic field, meaning the balance between the antibacterial property and mechanical strength.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfACS APPLIED MATERIALS & INTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleQuantitative Interpretation of Hydration Dynamics Enabled the Fabrication of a Zwitterionic Antifouling Surface-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorWoojin Choi-
dc.contributor.googleauthorJie Jin-
dc.contributor.googleauthorSohyeon Park-
dc.contributor.googleauthorJi-Yeong Kim-
dc.contributor.googleauthorMyung-Jin Lee-
dc.contributor.googleauthorHyeongdeok Sun-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorHwankyu Lee-
dc.contributor.googleauthorSung-Hwan Choi-
dc.contributor.googleauthorJinkee Hong-
dc.identifier.doi10.1021/acsami.9b21566-
dc.contributor.localIdA00247-
dc.contributor.localIdA04083-
dc.relation.journalcodeJ00004-
dc.identifier.eissn1944-8252-
dc.identifier.pmid31968161-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsami.9b21566-
dc.subject.keywordRaman spectroscopy-
dc.subject.keywordantibacterial property-
dc.subject.keywordantifouling property-
dc.subject.keywordbiomedical application-
dc.subject.keywordgrafting-
dc.subject.keywordhydration-
dc.subject.keywordmechanical strength-
dc.subject.keywordmedical device-
dc.subject.keywordremovable orthodontic retainer-
dc.subject.keywordzwitterionic brush-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor최성환-
dc.citation.volume12-
dc.citation.number7-
dc.citation.startPage7951-
dc.citation.endPage7965-
dc.identifier.bibliographicCitationACS APPLIED MATERIALS & INTERFACES, Vol.12(7) : 7951-7965, 2020-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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