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Long-Term Incidence and Growth of Chorioretinal Atrophy in Patients with Polypoidal Choroidal Vasculopathy

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dc.contributor.author고형준-
dc.contributor.author김민-
dc.contributor.author김성수-
dc.contributor.author박성은-
dc.contributor.author변석호-
dc.contributor.author이성철-
dc.contributor.author이승규-
dc.contributor.author최은영-
dc.date.accessioned2020-04-13T16:41:32Z-
dc.date.available2020-04-13T16:41:32Z-
dc.date.issued2020-
dc.identifier.issn0030-3755-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175470-
dc.description.abstractPURPOSE: To investigate the long-term incidence and growth rate of chorioretinal atrophy (CRA) in patients with polypoidal choroidal vasculopathy (PCV) and determine the associated risk factors. METHODS: The medical records of 88 patients with unilateral symptomatic PCV who received anti-vascular endothelial growth factor (anti-VEGF) injections with or without photodynamic therapy (PDT) were analyzed retrospectively. Near-infrared fundus imaging and spectral domain optical coherence tomography were used to measure the CRA area and growth rate. Kaplan-Meier survival analysis was performed to estimate the CRA incidence. Logistic and linear regression analyses were used to investigate risk factors (e.g., age, frequency of abnormal OCT findings, PDT history, total injection number, and choroidal thickness) associated with the CRA incidence and growth rate, respectively. RESULTS: The overall CRA incidence was 40.8% at 5 years. The absence of subretinal fluid, the presence of intraretinal fluid, and a thin choroid were significant risk factors for CRA occurrence with a history of PDT. Overall 5-year CRA growth rate was 0.69 mm2/year. Faster CRA growth was significantly related to the presence of subretinal hyperreflective material and thin choroid. PDT history was not significantly related to CRA growth. CONCLUSIONS: Thin choroid may be a significant risk factor for long-term development and growth of CRA in eyes with PCV. Intraretinal fluid seems to promote the development of CRA, while subretinal fluid seems to be associated with CRA prevention. The history of PDT was significantly related to the occurrence of CRA, but not to the growth rate of CRA.-
dc.description.statementOfResponsibilityrestriction-
dc.languageGerman-
dc.publisherKarger-
dc.relation.isPartOfOPHTHALMOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLong-Term Incidence and Growth of Chorioretinal Atrophy in Patients with Polypoidal Choroidal Vasculopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorEun Young Choi-
dc.contributor.googleauthorSung Eun Park-
dc.contributor.googleauthorSung Chul Lee-
dc.contributor.googleauthorHyoung Jun Koh-
dc.contributor.googleauthorSung Soo Kim-
dc.contributor.googleauthorSuk Ho Byeon-
dc.contributor.googleauthorMin Kim-
dc.contributor.googleauthorChristopher Seungkyu Lee-
dc.identifier.doi10.1159/000501724-
dc.contributor.localIdA00152-
dc.contributor.localIdA00455-
dc.contributor.localIdA00571-
dc.contributor.localIdA05758-
dc.contributor.localIdA01849-
dc.contributor.localIdA02873-
dc.contributor.localIdA02913-
dc.contributor.localIdA05056-
dc.relation.journalcodeJ02431-
dc.identifier.eissn1423-0267-
dc.identifier.pmid31454801-
dc.identifier.urlhttps://www.karger.com/Article/FullText/501724-
dc.subject.keywordAnti-vascular endothelialgrowth factor-
dc.subject.keywordChorioretinalatrophy-
dc.subject.keywordGeographic atrophy-
dc.subject.keywordPhotodynamic therapy-
dc.subject.keywordPolypoidal choroidal vasculopathy-
dc.subject.keywordRetinal pigment epithelial atrophy-
dc.contributor.alternativeNameKoh, Hyoung Jun-
dc.contributor.affiliatedAuthor고형준-
dc.contributor.affiliatedAuthor김민-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor박성은-
dc.contributor.affiliatedAuthor변석호-
dc.contributor.affiliatedAuthor이성철-
dc.contributor.affiliatedAuthor이승규-
dc.contributor.affiliatedAuthor최은영-
dc.citation.volume243-
dc.citation.number2-
dc.citation.startPage136-
dc.citation.endPage144-
dc.identifier.bibliographicCitationOPHTHALMOLOGICA, Vol.243(2) : 136-144, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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