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말초삽입 중심정맥관에서 채취한 혈액에서 동정된 Chryseobacterium hominis 1례 보고

Other Titles
 Case of Chryseobacterium hominis Isolated from Human Blood Drawn Through Peripherally Inserted Central Catheter 
 원동주  ;  변정현  ;  김명숙  ;  용동은 
 Laboratory Medicine Online, Vol.9(4) : 246-248, 2019 
Journal Title
 Laboratory Medicine Online 
Issue Date
Chryseobacterium ; Chryseobacterium hominis ; Catheter-related blood stream infection ; Bacteremia
Chryseobacterium hominis is non-fermenting Gram-negative rod that was first identified as a novel species in 2007. Here, we report the first clinical case of C. hominis bacteremia, which was confirmed by MALDI-TOF MS and 16S rRNA gene sequencing. A 16-year-old boy diagnosed with acute lymphoblastic leukemia was hospitalized for three months. Two sets of blood culture test through a peripherally inserted central catheter (PICC), which was inserted a month ago, was performed when his white blood cell count declined and he had a high fever. Colonies of medium sizes that looked round, mucoid, sticky, and grayish on blood and chocolate agar plates were observed. Identification of bacteria using the VITEK MALDI-TOF MS system (BioMérieux, France) was not successful and the VITEK 2 system (BioMérieux, USA) indicated Sphingomonas paucimobilis, with a questionable level of confidence (92%). However, Microflex LT Biotyper (Bruker Daltonics, Germany) showed C. homins (log score: 1.81) and sequence of 16S rRNA showed a 100% identity with C. hominis. Piperacillin-tazobactam was administered since the isolate was susceptible to piperacillin-tazobactam but C. hominis showed growth in the next four follow-up culture of blood drawn through PICC. The fever subsided only after PICC was changed. The clinical prognosis and antimicrobial susceptibility test of C. hominis should be further studied.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Byun, Jung-Hyun(변정현)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Won, Dongju(원동주) ORCID logo https://orcid.org/0000-0002-0084-0216
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