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Comparison of Sufentanil- and Fentanyl-based Intravenous Patient-controlled Analgesia on Postoperative Nausea and Vomiting after Laparoscopic Nephrectomy: A Prospective, Double-blind, Randomized-controlled Trial

Authors
 Hye-Mi Lee  ;  Hae Keum Kil  ;  Bon Nyeo Koo  ;  Min Sup Song  ;  Jin Ha Park 
Citation
 INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.17(2) : 207-213, 2020 
Journal Title
 INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 
Issue Date
2020
Keywords
fentanyl ; intravenous patient-controlled analgesia ; laparoscopic nephrectomy ; postoperative nausea and vomiting ; sufentanil
Abstract
Background: The incidence of postoperative nausea and vomiting (PONV) remains high. The effects of sufentanil for PONV is not firmly confirmed. The aim of this study was to compare the effect of sufentanil- and fentanyl-based intravenous patient-controlled analgesia (IV-PCA) on the incidence of PONV after laparoscopic nephrectomy. Methods: Eighty-six patients were randomly allocated to receive either the sufentanil (n =43) or fentanyl (n =43). IV-PCA was prepared using either sufentanil 3 µg/kg or fentanyl 20 µg/kg, ramosetron 0.3 mg, and ketorolac 120 mg. The primary outcome of was the incidence of PONV during 24 h after post anesthesia care unit (PACU) discharge. The secondary outcomes were the modified Rhodes index and patient satisfaction scores at 24 h after PACU discharge, need for rescue antiemetics, pain score, need for additional analgesics, and cumulative consumption of IV-PCA Results: The incidence of PONV was comparable between the sufentanil and fentanyl groups (64.3% vs. 65%, p = 0.946; respectively). The number of patients who required antiemetics (p = 0.946) and the modified Rhodes index at 24 h after post-anesthesia care unit discharge (p = 0.668) were also comparable in both groups. No significant differences were found in the secondary outcomes, including the analgesic profiles and adverse events between the groups. Conclusions: In conclusion, sufentanil- and fentanyl-based IV-PCA showed similar incidence of PONV with comparable analgesic effects after laparoscopic nephrectomy. Based on these results, we suggest that sufentanil and fentanyl may provide comparable effects for IV-PCA after laparoscopic nephrectomy.
Files in This Item:
T202000185.pdf Download
DOI
10.7150/ijms.39374
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koo, Bon-Nyeo(구본녀) ORCID logo https://orcid.org/0000-0002-3189-1673
Kil, Hae Keum(길혜금)
Park, Jin Ha(박진하) ORCID logo https://orcid.org/0000-0002-1398-3304
Song, Min sup(송민섭) ORCID logo https://orcid.org/0000-0003-2112-7046
Lee, Hye Mi(이혜미) ORCID logo https://orcid.org/0000-0002-0432-1878
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175241
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