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Dynamic predictive model for postoperative nausea and vomiting for intravenous fentanyl patient-controlled analgesia

DC FieldValueLanguage
dc.contributor.author김소연-
dc.contributor.author박경수-
dc.contributor.author송영-
dc.contributor.author채동우-
dc.contributor.author한동우-
dc.date.accessioned2020-02-26T06:38:17Z-
dc.date.available2020-02-26T06:38:17Z-
dc.date.issued2020-
dc.identifier.issn0003-2409-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175233-
dc.description.abstractPostoperative nausea and vomiting is the most common side-effect of opioid-based intravenous patient-controlled analgesia. Apfel's simplified risk score is popular but it has some limitations. We developed and validated a dynamic predictive model for nausea or vomiting up to 48 postoperative hours, available as an online web application. Fentanyl was used by 22,144 adult patients for analgesia after non-cardiac surgery under general anaesthesia: we randomly divided them into development (80%) and validation (20%) cohorts, repeated 100 times. We used linear discriminant analysis to select variables for multivariate logistic regression. The incidences of postoperative nausea or vomiting were: 0-48 h, 5691/22,144 (26%); 0-6 h, 2749/22,144 (12%); 6-12 h, 2687/22,144 (12%); 12-18 h, 2624/22,144 (12%); 18-24 h, 1884/22,144 (9%); and 24-48 h, 1082/22,144 (5%). The median (95%CI) area under the receiver operating characteristic curve was 0.72 (0.71-0.73) up to 48 postoperative hours compared with 0.65 (0.64-0.66) for the Apfel model, p < 0.001. The equivalent areas for 0-6 h, 6-12 h, 12-18 h, 18-24 h and 24-48 h were: 0.70 (0.69-0.72); 0.71 (0.69-0.73); 0.69 (0.68-0.71); 0.70 (0.67-0.72); and 0.69 (0.66-0.71), respectively. Our web application allows clinicians to calculate incidences of nausea and vomiting in patients receiving intravenous fentanyl for patient-controlled analgesia.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfANAESTHESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnalgesia, Patient-Controlled/adverse effects*-
dc.subject.MESHAnalgesics, Opioid-
dc.subject.MESHAnesthetics, Intravenous/adverse effects*-
dc.subject.MESHComorbidity-
dc.subject.MESHFemale-
dc.subject.MESHFentanyl/adverse effects*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMotion Sickness/epidemiology-
dc.subject.MESHPostoperative Nausea and Vomiting/diagnosis*-
dc.subject.MESHPostoperative Nausea and Vomiting/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSex Factors-
dc.subject.MESHSmoking/epidemiology-
dc.subject.MESHSurveys and Questionnaires*-
dc.titleDynamic predictive model for postoperative nausea and vomiting for intravenous fentanyl patient-controlled analgesia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorD. Chae-
dc.contributor.googleauthorS. Y. Kim-
dc.contributor.googleauthorY. Song-
dc.contributor.googleauthorW. Baek-
dc.contributor.googleauthorH. Shin-
dc.contributor.googleauthorK. Park-
dc.contributor.googleauthorD. W. Han-
dc.identifier.doi10.1111/anae.14849-
dc.contributor.localIdA00616-
dc.contributor.localIdA01422-
dc.contributor.localIdA01422-
dc.contributor.localIdA02036-
dc.contributor.localIdA02036-
dc.contributor.localIdA04014-
dc.contributor.localIdA04014-
dc.contributor.localIdA04274-
dc.contributor.localIdA04274-
dc.relation.journalcodeJ00128-
dc.identifier.eissn1365-2044-
dc.identifier.pmid31531854-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/anae.14849-
dc.subject.keywordfentanyl-
dc.subject.keywordintravenous patient-controlled analgesia-
dc.subject.keywordpostoperative nausea and vomiting-
dc.subject.keywordpredictive model-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.affiliatedAuthor김소연-
dc.contributor.affiliatedAuthor박경수-
dc.contributor.affiliatedAuthor박경수-
dc.contributor.affiliatedAuthor송영-
dc.contributor.affiliatedAuthor송영-
dc.contributor.affiliatedAuthor채동우-
dc.contributor.affiliatedAuthor채동우-
dc.contributor.affiliatedAuthor한동우-
dc.contributor.affiliatedAuthor한동우-
dc.citation.volume75-
dc.citation.number2-
dc.citation.startPage218-
dc.citation.endPage226-
dc.identifier.bibliographicCitationANAESTHESIA, Vol.75(2) : 218-226, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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