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Novel Associations between Related Proteins and Cellular Effects of High-Density Lipoprotein
DC Field | Value | Language |
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dc.contributor.author | 안수진 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2020-02-26T06:38:07Z | - |
dc.date.available | 2020-02-26T06:38:07Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175231 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL. METHODS: HDLs isolated from 48 participants were analyzed. Cholesterol efflux capacity, effect of HDL on nitric oxide production, and vascular cell adhesion molecule-1 expression were assessed. The relative abundance of identified proteins in the highest vs. lowest quartile was expressed using the normalized spectral abundance factor ratio. RESULTS: After adjustment by multiple testing, six proteins, thyroxine-binding globulin, alpha-1B-glycoprotein, plasma serine protease inhibitor, vitronectin, angiotensinogen, and serum amyloid A-4, were more abundant (relative abundance ratio ≥2) in HDLs with the highest cholesterol efflux capacity. In contrast, three proteins, complement C4-A, alpha-2-macroglobulin, and immunoglobulin mu chain C region, were less abundant (relative abundance ratio <0.5). In terms of nitric oxide production and vascular cell adhesion molecule-1 expression, no proteins showed abundance ratios ≥2 or <0.5 after adjustment. Proteins correlated with the functional parameters of HDL belonged to diverse biological categories. CONCLUSIONS: In summary, this study ranked proteins showing higher or lower abundance in HDLs with high functional capacities and newly identified multiple proteins linked to cholesterol efflux capacity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Novel Associations between Related Proteins and Cellular Effects of High-Density Lipoprotein | - |
dc.type | Article | - |
dc.contributor.college | Research Institutes (연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.googleauthor | Seungbum Choi | - |
dc.contributor.googleauthor | Yae Eun Park | - |
dc.contributor.googleauthor | Eun Jeong Cheon | - |
dc.contributor.googleauthor | Kyeong Yeon Kim | - |
dc.contributor.googleauthor | Miso Kim | - |
dc.contributor.googleauthor | Soo-jin Ann | - |
dc.contributor.googleauthor | Hye-Min Noh | - |
dc.contributor.googleauthor | Jaeho Lee | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Seung-Taek Lee | - |
dc.contributor.googleauthor | Cheolju Lee | - |
dc.contributor.googleauthor | Ji Eun Lee | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.identifier.doi | 10.4070/kcj.2019.0195 | - |
dc.contributor.localId | A02243 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 31845554 | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Cardiovascular diseases | - |
dc.subject.keyword | Immunity | - |
dc.subject.keyword | Lipoproteins | - |
dc.subject.keyword | Proteomics | - |
dc.contributor.alternativeName | Ann, Soo Jin | - |
dc.contributor.affiliatedAuthor | 안수진 | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e13 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.50(3) : e13, 2020 | - |
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