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Secukinumab demonstrates superior efficacy and a faster response in clearing skin in Asian subjects with moderate to severe plaque psoriasis compared with ustekinumab: Subgroup analysis from the CLEAR study

DC FieldValueLanguage
dc.contributor.author김태균-
dc.contributor.author이민걸-
dc.date.accessioned2020-02-26T06:32:54Z-
dc.date.available2020-02-26T06:32:54Z-
dc.date.issued2019-
dc.identifier.issn0385-2407-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175194-
dc.description.abstractThe 52-week results from the CLEAR (NCT02074982) study showed high and superior efficacy of secukinumab versus ustekinumab in clearing skin and improving patient-reported outcomes, with comparable safety profile in subjects with moderate to severe psoriasis. Here, we analyzed the efficacy and safety of secukinumab in Asian subjects from the CLEAR study. In this double-blind, phase IIIb study, eligible subjects with moderate to severe plaque psoriasis were randomized (1:1) to receive s.c. injection of secukinumab 300 mg or ustekinumab as per label. Of 62 subjects included in Asian subanalyses, 23 were randomized to secukinumab and 39 to ustekinumab. A significantly higher proportion of subjects achieved 90% or more improvement in Psoriasis Area and Severity Index (PASI 90) with secukinumab versus ustekinumab at week 16 (78.3% vs 35.9%, P = 0.0010) and at week 52 (60.9% vs 33.3%, P = 0.0196). Similarly, a higher proportion of subjects achieved PASI 100 with secukinumab versus ustekinumab at week 16 (43.5% vs 10.3%, P = 0.0029) and at week 52 (30.4% vs 12.8%, P = 0.0704). The median time to achieve 50% improvement in baseline PASI was 2.8 weeks in the secukinumab group versus 6.3 weeks in the ustekinumab group. The safety profile of secukinumab was in line with the known profile and no deaths occurred. Overall, 95.7% and 84.6% of subjects remained on secukinumab and ustekinumab, respectively. Similar to the core study, secukinumab showed sustained and superior efficacy with faster response versus ustekinumab, and no new or unexpected safety concerns were identified, in Asian subjects with moderate to severe plaque psoriasis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfJOURNAL OF DERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Monoclonal/administration & dosage*-
dc.subject.MESHAntibodies, Monoclonal/adverse effects-
dc.subject.MESHAntibodies, Monoclonal, Humanized-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHDermatologic Agents/administration & dosage*-
dc.subject.MESHDermatologic Agents/adverse effects-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Subcutaneous-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPsoriasis/diagnosis-
dc.subject.MESHPsoriasis/drug therapy*-
dc.subject.MESHPsoriasis/pathology-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSkin/drug effects-
dc.subject.MESHSkin/pathology-
dc.subject.MESHTime Factors-
dc.subject.MESHUstekinumab/administration & dosage*-
dc.subject.MESHUstekinumab/adverse effects-
dc.titleSecukinumab demonstrates superior efficacy and a faster response in clearing skin in Asian subjects with moderate to severe plaque psoriasis compared with ustekinumab: Subgroup analysis from the CLEAR study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorMin‐Geol Lee-
dc.contributor.googleauthorYu‐Huei Huang-
dc.contributor.googleauthorJoo‐Heung Lee-
dc.contributor.googleauthorSeung‐Chul Lee-
dc.contributor.googleauthorTae‐Gyun Kim-
dc.contributor.googleauthorDerrick Chen‐Wee Aw-
dc.contributor.googleauthorWeibin Bao-
dc.contributor.googleauthorCathleen Michelle A. Dee-
dc.contributor.googleauthorAdriana Guana-
dc.contributor.googleauthorTsen‐Fang Tsai-
dc.identifier.doi10.1111/1346-8138.15004-
dc.contributor.localIdA05324-
dc.contributor.localIdA02779-
dc.contributor.localIdA02779-
dc.relation.journalcodeJ01372-
dc.identifier.eissn1346-8138-
dc.identifier.pmid31342560-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/1346-8138.15004-
dc.subject.keywordAsian-
dc.subject.keywordefficacy-
dc.subject.keywordplaque psoriasis-
dc.subject.keywordsecukinumab-
dc.subject.keywordustekinumab-
dc.contributor.alternativeNameKim, Tae-Gyun-
dc.contributor.affiliatedAuthor김태균-
dc.contributor.affiliatedAuthor이민걸-
dc.contributor.affiliatedAuthor이민걸-
dc.citation.volume46-
dc.citation.number9-
dc.citation.startPage752-
dc.citation.endPage758-
dc.identifier.bibliographicCitationJOURNAL OF DERMATOLOGY, Vol.46(9) : 752-758, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

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