80 86

Cited 2 times in

Leukocyte Telomere Length Reflects Prenatal Stress Exposure, But Does Not Predict Atopic Dermatitis Development at 1 Year

 Dong In Suh  ;  Mi-Jin Kang  ;  Yoon Mee Park  ;  Jun-Kyu Lee  ;  So-Yeon Lee  ;  Youn Ho Sheen  ;  Kyung Won Kim  ;  Kangmo Ahn  ;  Hye-Sung Won  ;  Mi-Young Lee  ;  Suk-Joo Choi  ;  Ja-Young Kwon  ;  Hee Jin Park  ;  Jong Kwan Jun  ;  Soo-Jong Hong  ;  Young Yull Koh 
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.11(3) : 357-366, 2019 
Journal Title
Issue Date
Atopic dermatitis ; child ; cohort studies ; cord blood ; psychological stress ; telomere shortening
PURPOSE: Prenatal maternal stress affects offspring's atopic dermatitis (AD) development, which is thought to be mediated by the oxidative stress. We aimed to evaluate the difference in leukocyte telomere length (LTL), a marker for exposure to oxidative stress, according to the prenatal stress exposure and the later AD development. METHODS: From a birth cohort (the COhort for Childhood Origin of Asthma and allergic diseases) that had displayed a good epidemiologic association between the exposure to prenatal stress and AD development in the offspring, we selected 68 pairs of samples from 4 subject groups based on the level of prenatal maternal stress and later AD development. The LTL was measured from both cord blood and 1-year peripheral blood, and their LTLs were compared between subject groups. Finally, the proportion of AD development was examined in the subject groups that are reclassified based on subjects' exposure to prenatal stress and there LTL. RESULTS: Cord-blood LTL was shorter in prenatally stressed infants than in unstressed ones (P = 0.026), which difference was still significant when subjects became 1 year old (P = 0.008). LTL of cord blood, as well as one of the 1-year peripheral blood, was not different according to later AD development at 1 year (P = 0.915 and 0.174, respectively). Shorter LTL made no increase in the proportion of later AD development in either prenatally high-stressed or low-stressed groups (P = 1.000 and 0.473, respectively). CONCLUSIONS: Cord-blood LTL may reflect subjects' exposure to maternal prenatal stress. However, the LTL shortening is not a risk factor of increasing AD development until the age of 1, and a longer investigation may be necessary for validation. Currently, the results doubt the role of LTL shortening as a marker for risk assessment tool for the prenatal stress associated with AD development in the offspring.
Files in This Item:
T201905798.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.