76 118

Cited 0 times in

차세대 염기서열 분석법과 항암요법

DC FieldValueLanguage
dc.contributor.author손주혁-
dc.date.accessioned2020-02-26T06:30:34Z-
dc.date.available2020-02-26T06:30:34Z-
dc.date.issued2019-
dc.identifier.issn1975-8456-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175179-
dc.description.abstractOver the last two decades, the systemic treatment of cancer has evolved from cytotoxic chemotherapy to targeted therapy and now immunotherapy. Next-generation sequencing (NGS) is entering clinical applications for cancer treatment through the help of more powerful computational analyses. The increasing number of targeted therapies approved by regulatory authorities (RAs) with or without biomarkers necessitates the screening of multiple biomarkers using NGS, which is now approved and reimbursed by Korean RAs for some types of malignancies. However, the clinical utility of NGS remains to be established as a prerequisite for its routine incorporation into clinical practice. Currently, the best scenario of NGS use in clinics is to enroll patients into clinical trials based on the detection of biomarkers, but this is only possible in the hospitals conducting the specific trial. The other scenario is the off-label use of a targeted drug, but this requires social consensus for future implementation. The clinical applications of NGS are expanding in terms of its platforms, from targeted sequencing to whole exome and RNA sequencing, and in terms of systemic therapy, from targeted therapy to immunotherapy. Research into tumor mutational burden and neoantigens is shedding new light on the clinical use of NGS in immunotherapy.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한의사협회-
dc.relation.isPartOfJOURNAL OF THE KOREAN MEDICAL ASSOCIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title차세대 염기서열 분석법과 항암요법-
dc.title.alternativeNext generation sequencing and anti-cancer therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor손주혁-
dc.contributor.localIdA01995-
dc.relation.journalcodeJ01833-
dc.identifier.eissn2093-5951-
dc.subject.keywordNext generation sequencing-
dc.subject.keywordCancer-
dc.subject.keywordTargeted therapy-
dc.subject.keywordImmunotherapy-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.affiliatedAuthor손주혁-
dc.citation.volume62-
dc.citation.number2-
dc.citation.startPage119-
dc.citation.endPage129-
dc.identifier.bibliographicCitationJOURNAL OF THE KOREAN MEDICAL ASSOCIATION, Vol.62(2) : 119-129, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.