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Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet
DC Field | Value | Language |
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dc.contributor.author | 이형근 | - |
dc.date.accessioned | 2020-02-26T06:29:57Z | - |
dc.date.available | 2020-02-26T06:29:57Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175174 | - |
dc.description.abstract | Interleukin-22 (IL-22) is a cytokine with important functions in host defense and inflammatory responses and has recently been suggested to play a role in immune-inflammatory system in the context of obesity and its metabolic consequences. The specific cellular targets and mechanisms of IL-22-mediated obesity are largely unknown however. We here identified a previously unknown subset of monocyte-derived Duffy antigen receptors for chemokines (DARC)+ macrophages in epididymal fat adipose tissue and found that they are preferentially recruited into the crown-like structures of adipose tissue in the mouse upon high fat diet-induced obesity. Importantly, DARC+ macrophages highly express the IL-22 receptor (IL-22Ra1). Exposure to recombinant IL-22 shifts macrophages to an alternative M2 polarization pathway and augments DARC expression via a STAT5b signaling axis. STAT5b directly binds to the DARC promoter and a STAT5 inhibitor abrogates the IL-22-mediated induction of DARC. These M2-like DARC+ subpopulations of monocytes/macrophages were elevated in obese db/db mice compared to WT lean mice. Furthermore, subsets of CD14+ and/or CD16+ monocytes/macrophages within human peripheral blood mononuclear cell populations express DARC and the prevalence of these subsets is enhanced by IL-22 stimuli. This suggested that IL-22 is a critical cytokine that promotes the infiltration of adipose tissue macrophages, that regulate inflammatory processes. Taken together, our present findings provide important insights into the molecular mechanism by which IL-22 signal modulates DARC expression in M2-like macrophages. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet | - |
dc.title.alternative | Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Eun-Young Kim | - |
dc.contributor.googleauthor | Hye Mi Noh | - |
dc.contributor.googleauthor | Bongkun Choi | - |
dc.contributor.googleauthor | Ji-Eun Park | - |
dc.contributor.googleauthor | Ji-Eun Kim | - |
dc.contributor.googleauthor | Youngsaeng Jang | - |
dc.contributor.googleauthor | Hyung Keun Lee | - |
dc.contributor.googleauthor | Eun-Ju Chang | - |
dc.identifier.doi | 10.3390/cells8121587 | - |
dc.contributor.localId | A03303 | - |
dc.relation.journalcode | J03774 | - |
dc.identifier.pmid | 31817755 | - |
dc.subject.keyword | Duffy antigen receptor for chemokines (DARC) | - |
dc.subject.keyword | adipose tissue | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | interleukin 22 | - |
dc.subject.keyword | monocyte-derived macrophages | - |
dc.contributor.alternativeName | Lee, Hyung Keun | - |
dc.contributor.affiliatedAuthor | 이형근 | - |
dc.citation.volume | 8 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E1587 | - |
dc.identifier.bibliographicCitation | CELLS, Vol.8(12) : E1587, 2019 | - |
dc.identifier.rimsid | 63435 | - |
dc.type.rims | ART | - |
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