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Survival and prognostic factors of anaplastic gliomas and prognostic impact of the 2016 WHO classification

Other Titles
 역형성 신경교종에서 생존율과 예후인자 분석 및 2016 WHO 분류의 예후적 의의 
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Objective To investigate the survival and prognostic factors in anaplastic gliomas and whether the updated 2016 WHO classification in anaplastic gliomas has more prognostically predictive impact for survival than 2007 WHO classification. Methods A total of 113 consecutive patients with newly diagnosed anaplastic gliomas by 2007 WHO classification at our hospital from Jan. 2001 to Dec. 2013 were enrolled in this study. We integrated the molecular profiles in each patient and reclassified the diagnosis with the molecular information according to 2016 WHO classification. The Kaplan Meier methods, a multivariate Cox proportional regression analysis, Contal and O’Quigley method and a time-dependent ROC curve method were used for statistical analysis. Results The overall survival of total group of anaplastic gliomas was 48.4 months, of which the AA, IDH-wildtype group was 21.5 months. The progression free survival of total group was 31.8 months, of which the AA, IDH-wildtype group was 16.4 months. Age, postoperative tumor volume, extent of resection measured in T2-weighted MRI, and deep location of tumor were factors associated with the overall survival. And cut off value of tumor resection were 99.96% in contrast enhanced T1-weighted MRI and 85.64% in T2-weighted MRI. The 2016 WHO classification significantly increased predictability for survival across the entire follow-up period. The difference (iAUC of 2016 model – iAUC of 2007 model) was statistically significant (estimated difference was 0.024, 95% CI is 0.022–0.075). Conclusion We investigated the survival and prognostic factors in anaplastic gliomas and showed that 2016 WHO classification of tumors of the CNS may be more predictable in survival than 2007 WHO classification in patients with anaplastic gliomas.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 5. Others
Yonsei Authors
Hong, Je Beom(홍재범)
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