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Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells

Authors
 Galam Leem  ;  Beom Kyung Kim  ;  Eui-Cheol Shin  ;  Jun Yong Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.61(1) : 100-102, 2020 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2020
Keywords
Autoimmune hepatitis ; acute hepatitis A ; inflammatory conversion of Treg cells ; regulatory T cells
Abstract
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
Files in This Item:
T202000163.pdf Download
DOI
10.3349/ymj.2020.61.1.100
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Shin, Ui Cheol(신의철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174924
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