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Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core

Authors
 Wha Young Kim  ;  Wen Ting Cai  ;  Ju Kyong Jang  ;  Jeong-Hoon Kim 
Citation
 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.24(1) : 121-126, 2020 
Journal Title
 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY 
ISSN
 1226-4512 
Issue Date
2020
Keywords
Drug addiction ; Glycogen synthase kinase ; Nucleus accumbens ; Protein kinase B ; Signal transduction
Abstract
The ezrin-radixin-moesin (ERM) proteins are a family of membrane-associated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases phosphorylation levels of these proteins in the nucleus accumbens (NAcc), an important neuronal substrate mediating rewarding effects of drugs of abuse. In the present study, we further examined what molecular pathways may be involved in this process. By direct microinjection of LY294002, a PI3 kinase inhibitor, or of S9 peptide, a proposed GSK3β activator, into the NAcc core, we found that phosphorylation levels of ERM as well as of GSK3β in this site are simultaneously decreased. These results indicate that ERM proteins are under the regulation of Akt-GSK3β signaling pathway in the NAcc core. The present findings have a significant implication to a novel signal pathway possibly leading to structural plasticity in relation with drug addiction.
Files in This Item:
T202000136.pdf Download
DOI
10.4196/kjpp.2020.24.1.121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Hoon(김정훈) ORCID logo https://orcid.org/0000-0001-7095-3729
Kim, Wha Young(김화영) ORCID logo https://orcid.org/0000-0003-1744-7012
Cai, Wen Ting(채문정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174911
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