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Association of serum carbohydrate antigen 19-9 level with arterial stiffness and coronary artery calcification in middle-aged and older adults: a cross-sectional study
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.date.accessioned | 2020-02-11T06:50:52Z | - |
dc.date.available | 2020-02-11T06:50:52Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174872 | - |
dc.description.abstract | OBJECTIVES: Emerging evidence suggests that serum carbohydrate antigen 19-9 level is elevated in type 2 diabetes and metabolic syndrome, which are closely related with atherosclerotic cardiovascular disease. This study aimed to determine whether serum carbohydrate antigen 19-9 level is related to atherosclerosis as measured by brachial-ankle pulse wave velocity (PWV) and coronary calcium score (CCS). METHODS: This cross-sectional study comprised 1732 Korean adults aged at least 45 years who underwent a health examination program. Serum carbohydrate antigen 19-9 level was quantified by chemiluminescence immunoassay and categorized as quartiles, after exclusion of participants with carbohydrate antigen 19-9 levels more than 30 U/ml to rule out hidden malignancy: Q1: 4.5 or less, Q2: 4.6-7.5, Q2: 7.6-12.2, and Q4: at least 12.3 ng/ml. High brachial-ankle PWV was defined as a level greater than 1570 cm/s (>75th percentile), and high CCS was defined as a level over 100. The odds ratios and 95% confidence intervals for high PWV and high CCS were calculated across serum carbohydrate antigen 19-9 quartiles using multiple logistic regression analysis. RESULTS: The prevalence of high PWV and high CCS increased with serum carbohydrate antigen 19-9 quartile. Compared with the lowest quartile, the odds ratios (95% confidence intervals) of the highest carbohydrate antigen 19-9 quartile for high PWV and high CCS were 1.61 (1.05-2.48) and 2.03 (1.17-3.54), respectively, after adjusting for age, sex, BMI, smoking status, alcohol consumption, regular exercise, fasting plasma glucose, total cholesterol, hypertension, type 2 diabetes, and dyslipidemia. CONCLUSION: We found that serum carbohydrate antigen 19-9 level was positively and independently associated with arterial stiffness and coronary artery calcification. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of serum carbohydrate antigen 19-9 level with arterial stiffness and coronary artery calcification in middle-aged and older adults: a cross-sectional study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1097/HJH.0000000000002217 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J01448 | - |
dc.identifier.eissn | 1473-5598 | - |
dc.identifier.pmid | 31460992 | - |
dc.identifier.url | https://insights.ovid.com/crossref?an=00004872-202001000-00015 | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 101 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, Vol.38(1) : 95-101, 2020 | - |
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