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Clinical characteristics and treatment outcomes of patients with macrolide-resistant Mycobacterium avium complex pulmonary disease: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 박고은 | - |
dc.contributor.author | 박영목 | - |
dc.contributor.author | 이은혜 | - |
dc.contributor.author | 정인경 | - |
dc.date.accessioned | 2020-02-11T06:47:28Z | - |
dc.date.available | 2020-02-11T06:47:28Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174847 | - |
dc.description.abstract | BACKGROUND: Macrolide is a key drug in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD). Macrolide-resistant MAC is gaining importance, but there are little data in clinical characteristics and treatment outcomes of macrolide-resistant MAC-PD (MR-MAC-PD). METHODS: We performed a systematic review and meta-analysis of published studies reporting clinical characteristics and treatment outcomes of patients with MR-MAC-PD. Risk of bias was assessed using the modified Newcastle-Ottawa Scale. RESULTS: Nine studies (seven retrospective and two prospective) comprising 319 patients were identified through a database search. Around 73% were women, and 52% had the fibrocavitary form. Pooled sputum culture conversion rate after combined multiple antibiotics or surgical resection was 21% (95% confidence interval [CI], 14-30%), and the one-year all-cause mortality was 10% (95% CI, 5-20%). There was no significant difference in treatment outcomes between nodular bronchiectatic and fibrocavitary types. CONCLUSIONS: Even combination therapy with fluoroquinolone, aminoglycoside, and surgical resection, the treatment outcomes of MR-MAC-PD were poor. The investigation of new treatment modalities is urgent. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central Ltd | - |
dc.relation.isPartOf | RESPIRATORY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical characteristics and treatment outcomes of patients with macrolide-resistant Mycobacterium avium complex pulmonary disease: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Youngmok Park | - |
dc.contributor.googleauthor | Eun Hye Lee | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.contributor.googleauthor | Goeun Park | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1186/s12931-019-1258-9 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A05827 | - |
dc.contributor.localId | A05828 | - |
dc.contributor.localId | A03053 | - |
dc.contributor.localId | A03693 | - |
dc.relation.journalcode | J02616 | - |
dc.identifier.eissn | 1465-993X | - |
dc.identifier.pmid | 31852452 | - |
dc.subject.keyword | Clarithromycin | - |
dc.subject.keyword | Drug resistance | - |
dc.subject.keyword | Macrolides | - |
dc.subject.keyword | Mycobacterium avium complex | - |
dc.subject.keyword | Mycobacterium avium-intracellulare infection | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 박고은 | - |
dc.contributor.affiliatedAuthor | 박영목 | - |
dc.contributor.affiliatedAuthor | 이은혜 | - |
dc.contributor.affiliatedAuthor | 정인경 | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 286 | - |
dc.identifier.bibliographicCitation | RESPIRATORY RESEARCH, Vol.20(1) : 286, 2019 | - |
dc.identifier.rimsid | 63400 | - |
dc.type.rims | ART | - |
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