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Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer

Authors
 Youngbae Jeon  ;  Eun Jung Park  ;  Jin Hong Lim  ;  Seung Hyuk Baik 
Citation
 WORLD JOURNAL OF SURGICAL ONCOLOGY, Vol.17(1) : 214, 2019 
Journal Title
 WORLD JOURNAL OF SURGICAL ONCOLOGY 
Issue Date
2019
Keywords
Colorectal cancer ; Cytoreductive surgery ; Hyperthermic intraperitoneal chemotherapy ; Liver metastases ; Liver resection ; Peritoneal metastases
Abstract
BACKGROUND: This study aimed to evaluate the clinical outcomes of concurrent liver resection with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in colorectal cancer patients with synchronous liver and peritoneal metastases. METHODS: Patients with colorectal liver and peritoneal metastasis who underwent complete cytoreduction and hyperthermic intraperitoneal chemotherapy with concurrent liver surgery between September 2014 and July 2018 were included. Perioperative outcomes, overall survival, and progression-free survival were analyzed retrospectively. RESULTS: In total, 22 patients were included. The median peritoneal cancer index was 13 (range, 0-26), and the median number of liver metastases was 3 (range, 1-13). The mean total operative time was 11.4 ± 2.6 h. Minor postoperative complications (Clavien-Dindo grade I-II) were reported in 10 patients (45.5%), and major postoperative complications (grade III-V) were reported in five patients (22.7%), including one mortality patient. The median overall survival since diagnosis with metastasis was 27.4 months. The median overall survival since surgical intervention and the progression-free survival were 16.7 months and 7.1 months, respectively. CONCLUSIONS: This short-term follow-up study showed that, in an experienced center, combined resection with hyperthermic intraperitoneal chemotherapy for colorectal liver and peritoneal metastases was feasible and safe with acceptable oncologic outcomes.
Files in This Item:
T201905514.pdf Download
DOI
10.1186/s12957-019-1746-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Eun Jung(박은정) ORCID logo https://orcid.org/0000-0002-4559-2690
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Lim, Jin Hong(임진홍)
Jeon, Youngbae(전영배)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174766
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