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The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study

Authors
 Jae Ho Byun  ;  Joong Bae Ahn  ;  Sun Young Kim  ;  Jung Hun Kang  ;  Dae Young Zang  ;  Seok Yun Kang  ;  Myoung Joo Kang  ;  Byoung Yong Shim  ;  Sun Kyung Baek  ;  Bong-Seog Kim  ;  Kyung Hee Lee  ;  Soon Il Lee  ;  Sang-Hee Cho  ;  Byeong Seok Sohn  ;  Samyong Kim  ;  In Gyu Hwang  ;  Eun Mi Nam  ;  Bong-Gun Seo  ;  Sang Cheul Oh  ;  Myung-Ah Lee  ;  Sang-Cheol Lee  ;  Ji Hyung Hong  ;  Young Suk Park 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.34(1) : 165-177, 2019 
Journal Title
 KOREAN JOURNAL OF INTERNAL MEDICINE 
ISSN
 1226-3303 
Issue Date
2019
MeSH
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology* ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/secondary ; Lung Neoplasms/secondary ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Mutation ; Neoplasm Metastasis/pathology ; Ovarian Neoplasms/secondary ; Peritoneal Neoplasms/secondary ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Proteins p21(ras)/genetics ; Republic of Korea
Keywords
Colorectal neoplasms ; Primary tumor location ; Survival
Abstract
BACKGROUND/AIMS: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). METHODS: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were analyzed using Cox proportional hazards regression models. RESULTS: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.7] or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. CONCLUSION: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC.
Files in This Item:
T201905435.pdf Download
DOI
10.3904/kjim.2016.348
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174745
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