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Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

Authors
 Nan Li  ;  Junjie Piao  ;  Xinyue Wang  ;  Ki-Yeol Kim  ;  Jung Yoon Bae  ;  Xiangshan Ren  ;  Zhenhua Lin 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.51(4) : 1653-1665, 2019 
Journal Title
 CANCER RESEARCH AND TREATMENT 
ISSN
 1598-2998 
Issue Date
2019
Keywords
Apoptosis ; Cell cycle ; Paip1 ; Proliferation ; Uterine cervical neoplasms
Abstract
PURPOSE: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. Materials and Methods: The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression. RESULTS: Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth. CONCLUSION: Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
Files in This Item:
T201905046.pdf Download
DOI
10.4143/crt.2018.544
Appears in Collections:
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Bae, Jung Yoon(배정윤) ORCID logo https://orcid.org/0000-0001-8342-6987
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174622
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