55 123

Cited 0 times in

PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice

DC FieldValueLanguage
dc.contributor.author조남훈-
dc.contributor.author현영민-
dc.date.accessioned2020-02-11T06:16:59Z-
dc.date.available2020-02-11T06:16:59Z-
dc.date.issued2019-
dc.identifier.issn2314-7156-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174618-
dc.description.abstractFine particulate matter 2.5 (PM2.5) is a harmful air pollutant currently threatening public health. Although many studies have been performed on the general negative effects of PM2.5 in mice and humans, the migration patterns of various immune cells in response to PM2.5 exposure remain unclear. In this study, we aimed to investigate the immune cell migratory response in the lung and the liver of intratracheally PM2.5-inoculated mice. To investigate the migration trajectory of immune cells in the lung and the liver tissues of mice, we employed microscopic tools including two-photon intravital imaging, histological analysis, and transmission electron microscopy. Our data from two-photon intravital imaging showed that there was no significant difference in the number of infiltrated neutrophils in the lung and the liver of PM2.5-treated mice, compared to the nontreated condition. However, from the histological analysis and the transmission electron microscopy after vascular perfusion to remove intravascular leukocytes, we observed that some leukocytes were frequently observed in the lung and the liver of PM2.5-treated mice. Interestingly, quantification of leukocyte population using flow cytometry showed significant increase of neutrophils and macrophages in the lung, but not much in the liver, 24 h post-PM2.5 treatment. These data imply that two-photon intravital imaging of the lung and the liver actually visualized neutrophils, which were adherent to the luminal side of the vasculature. We then conducted mRNA microarray analysis to further observe how PM2.5 affects gene expression patterns in the lung and the liver. PM2.5 treatment changed the mRNA expression associated with the IL-17 signaling pathway in the lung and changed the mRNA expression associated with metabolic pathways in the liver. In summary, these results suggest that the immune response in the lung is distinctly regulated from that in the liver under acute PM2.5-induced inflammation and that these organs consequently are regulated via distinct signaling pathways.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHindawi Publishing Corporation-
dc.relation.isPartOfJOURNAL OF IMMUNOLOGY RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSoi Jeong-
dc.contributor.googleauthorSang A Park-
dc.contributor.googleauthorInwon Park-
dc.contributor.googleauthorPilhan Kim-
dc.contributor.googleauthorNam Hoon Cho-
dc.contributor.googleauthorJin Won Hyun-
dc.contributor.googleauthorYoung-Min Hyun-
dc.identifier.doi10.1155/2019/3486841-
dc.contributor.localIdA03812-
dc.contributor.localIdA04814-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ03015-
dc.identifier.eissn2314-8861-
dc.identifier.pmid31871955-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthor조남훈-
dc.contributor.affiliatedAuthor현영민-
dc.contributor.affiliatedAuthor현영민-
dc.citation.volume2019-
dc.citation.startPage3486841-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY RESEARCH, Vol.2019 : 3486841, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.