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Is Early Progression to Bilateral Involvement in Menière's Disease a Poor Prognostic Indicator?

Authors
 Hyun Jin Lee  ;  Jeon Mi Lee  ;  Dae Bo Shim  ;  Jinsei Jung  ;  Sang Hyun Kwak  ;  Sung Huhn Kim 
Citation
 OTOLOGY & NEUROTOLOGY, Vol.40(10) : 1333-1338, 2019 
Journal Title
 OTOLOGY & NEUROTOLOGY 
ISSN
 1531-7129 
Issue Date
2019
Abstract
OBJECTIVE: To investigate differences in the clinical features of bilateral Menière's disease (BMD) with early and late bilateral involvement. STUDY DESIGN: A retrospective case-comparison study. SETTING: Tertiary referral center. PATIENTS: In total, 25 patients with definite BMD were enrolled. Patients with bilateral involvement with a transition interval shorter than 1 month were considered to have synchronous BMD, whereas the others had metachronous BMD. INTERVENTIONS: We investigated differences in prognosis as defined by changes in the number of vertigo attacks after treatment, demographics, comorbidities, and inner ear function according to the transition interval from unilateral to bilateral involvement. MAIN OUTCOME MEASURE: We investigated other appropriate cut-off values in the interval from first- to second-ear involvement to predict poor prognosis. RESULTS: Receiver operating characteristic curve analysis revealed that a cut-off value of < 18-month interval exhibited maximum sensitivity and specificity for predicting poor prognosis. According to this value, we categorized patients into the early bilateral involvement group (EBIG, < 18 months' interval) and the late bilateral involvement group (LBIG, ≥ 18 months' interval). Patients with synchronous BMD and patients in the EBIG group exhibited poorer prognosis compared with patients with metachronous BMD and those in LBIG (p = 0.011 and p ≤ 0.001). Demographics, hearing threshold, vestibular deficit, and comorbidities were not significantly different between the two groups (p > 0.05). None of the patients exhibited systemic autoimmune disease. CONCLUSION: BMD with early bilateral progression exhibited poorer prognosis compared with late bilateral progression.
Full Text
https://insights.ovid.com/crossref?an=00129492-201912000-00019
DOI
10.1097/MAO.0000000000002368
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Sanghyun(곽상현) ORCID logo https://orcid.org/0000-0002-2827-8456
Kim, Sung Huhn(김성헌)
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174534
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