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A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells

Authors
 So Hee Dho  ;  Eun Ha Cho  ;  Ji Yeon Lee  ;  So‑Young Lee  ;  Sung Hee Jung  ;  Lark Kyun Kim  ;  Jae Cheong Lim 
Citation
 ONCOLOGY REPORTS, Vol.42(6) : 2686-2693, 2019 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
2019
Abstract
In recent years, efforts to treat cancer by improving the immune function of patients have received a great deal of attention. As part of the immune system, complement is also under such evaluation. Among the many components of the complement system, complement decay accelerating factor (CD55 or DAF) is known to inhibit complement‑mediated cell lysis. However, little is known about the role of CD55 in terms of cancer therapy. The present study aimed to demonstrate that increased levels of CD55 are strongly correlated with the progression of colorectal cancer. A novel CD55 chimeric monoclonal antibody was developed that may boost the immune response, thereby suppressing cancer. The CD55 antibody treatment activated complement and therefore suppressed the proliferation, invasion and migration of colorectal cancer cells. This tumoricidal activity is partly explained by the inflammatory response via the activation of proinflammatory cytokines. In addition, the CD55 antibody treatment synergistically enhanced the tumoricidal activity of 5‑FU in colorectal cancer cells, suggesting that combined treatment may be a better strategy in colorectal cancer therapy.
Full Text
https://www.spandidos-publications.com/or/42/6/2686
DOI
10.3892/or.2019.7337
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
Dho, So Hee(도소희) ORCID logo https://orcid.org/0000-0001-7343-713X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174532
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