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Effects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial

DC FieldValueLanguage
dc.contributor.author김응권-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author전익현-
dc.contributor.author최영준-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author전익현-
dc.contributor.author최영준-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author전익현-
dc.contributor.author최영준-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author전익현-
dc.contributor.author최영준-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author이형근-
dc.contributor.author전익현-
dc.contributor.author최영준-
dc.date.accessioned2020-02-11T02:22:10Z-
dc.date.available2020-02-11T02:22:10Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174482-
dc.description.abstractDry eye disease (DED) after cataract surgery has become a critical concern, and various therapeutic options have been developed. Recently, preservative-free diquafosol ophthalmic solution has been introduced; however, its therapeutic effect on DED after cataract surgery has not been reported. We investigated the efficacy of preservative-free diquafosol in patients with pre-existing DED after cataract surgery. We divided subjects who were diagnosed with DED and scheduled to undergo cataract surgery, into 3 groups (preservative-free diquafosol, group 1; preservative-containing diquafosol, group 2; preservative-free hyaluronate, group 3), and each eye drops was administered 6 times daily after surgery. Tear break up time (TBUT), Ocular Surface Disease Index (OSDI), corneal staining score, lid margin abnormality, and meibum quality improved over time in group 1. Groups 1 and 2 had significantly superior TBUT, meibomian gland dysfunction grade, and meibomian gland expressibility throughout the study period than group 3. Meibum quality of group 1 was significantly better than group 2 at 1 and 3 months after surgery. Preservative-free diquafosol showed better efficacy in treating DED after cataract surgery than preservative-containing diquafosol or preservative-free hyaluronate. Preservative-free diquafosol may serve as a reliable option for the management of patients with pre-existing DED after phacoemulsification.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffects of Preservative-free 3% Diquafosol in Patients with Pre-existing Dry Eye Disease after Cataract Surgery: A Randomized Clinical Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학교실)-
dc.contributor.googleauthorIkhyun Jun-
dc.contributor.googleauthorSeonghee Choi-
dc.contributor.googleauthorGeun Young Lee-
dc.contributor.googleauthorYoung Joon Choi-
dc.contributor.googleauthorHyung Keun Lee-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorTae-im Kim-
dc.identifier.doi10.1038/s41598-019-49159-0-
dc.contributor.localIdA00831-
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dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid31477748-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.affiliatedAuthor김응권-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor김태임-
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dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor이형근-
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dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor김태임-
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dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor김태임-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor서경률-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor이형근-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor전익현-
dc.contributor.affiliatedAuthor최영준-
dc.contributor.affiliatedAuthor최영준-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage12659-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.9(1) : 12659, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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