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Newly identified set of obesity-related genotypes and abdominal fat influence the risk of insulin resistance in a Korean population

Authors
 Minjoo Kim  ;  Sarang Jeong  ;  Hye Jin Yoo  ;  Hyoeun An  ;  Sun Ha Jee  ;  Jong Ho Lee 
Citation
 CLINICAL GENETICS, Vol.95(4) : 488-495, 2019 
Journal Title
 CLINICAL GENETICS 
ISSN
 0009-9163 
Issue Date
2019
Keywords
abdominal obesity ; genetic risk score ; genome-wide association study ; insulin resistance ; obesity
Abstract
We aimed to identify obesity-related single-nucleotide polymorphism (SNP) loci in a Korean population and construct an obesity genetic risk score (GRS) to examine the association of the genetic predisposition to obesity with insulin resistance (IR). In total, 9675 subjects were included, and 7666 of these subjects were used for replication. A GRS was constructed using the SNP loci that overlapped in both cohort sets. The subjects showed a trend toward an increase in body mass index, waist circumference, systolic/diastolic blood pressure, homeostatic model assessment (HOMA)-IR, HOMA-B, and levels of insulin, triglyceride, and alanine aminotransferase across the tertiles of obesity GRS, while the adiponectin level showed a trend toward a decrease with increasing GRS. The associations between the obesity GRS and the measures of fasting insulin, HOMA-IR, and adiponectin were significant after adjusting for confounding factors. Moreover, a significant association between obesity GRS and HOMA-IR was observed in subjects with abdominal obesity. The present results indicate that a predisposition to obesity may affect IR in the Korean population and that abdominal fat may alter or modify the genetic effects. Furthermore, the set of obesity-related genotypes and abdominal fat may play interactive roles in determining the risk of IR.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/cge.13509
DOI
10.1111/cge.13509
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174471
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