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신경결찰로 인한 이질토에서 Metabotrophic Glutamate 5형 수용체의 변화에 대한 연구

Other Titles
 The Changes of Metabotrophic Glutamate Receptor type 5 in Allodynia Induced by Nerve Ligation 
 Korean Journal of Pain (대한통증학회지), Vol.12(1) : 8-15, 1999 
Journal Title
 Korean Journal of Pain (대한통증학회지) 
Issue Date
Following peripheral nerve injury, rats will show a tactile allodynia and hyperalgesia. But the mech- anism of allodynia is still obscure. The present studies, using rats rendered allodynia by loosely con- strictive ligation of the common sciatic nerve (Bennett Model) and tight ligation of L5 & L6 spinal nerve (Chung Model), aimed to investigate the changes of metabotrophic glutamate receptor type 5 on the development of tactile allodynia. Male Sprague-Dawley rats (130-200 g) were anesthetized with halothane, the rats were randomly divided into one of these three groups, Group 1 (Sham operation), Group 2 (Bennett model) and Group 3 (Chung model). Seven days after surgical procedure, the animal was reanesthetized and decapitated. The spinal cord was quickly removed and stored at deep freezer for polymerase chain reaction (RT-PCR). In Group 2 &3, rats showed that tactile allodynia checked by up-down method with calibrated 8 von Frey hair. The level of gene expression of mGluR5 mRNA was significantly increased in group 2 and 3. These increases was significantly different from sham operation, group l. It was also showed that the increasing patterns of group 2 and 3 in the gene expression were similar correlation with the results of the threshold for tactile allodynia on von Frey hair test. Even though there were some differences between Bennett model and Chung model, these results suggested that mGluR5 had partly attributed to making a tactile allodynia from these models.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Youn Woo(이윤우)
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