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유방암 환자에서 HLA-A2와 c-erbB2의 발현

DC FieldValueLanguage
dc.contributor.author박전한-
dc.contributor.author정우희-
dc.date.accessioned2020-01-23T05:29:58Z-
dc.date.available2020-01-23T05:29:58Z-
dc.date.issued1999-
dc.identifier.issn1598-3641-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174335-
dc.description.abstractPurpose: Oncogene c-erbB2 produces a transmembrane protein similar in structure to the tyrosine kinase family. Overexpression of c-erbB2 is known to lower the survival rate of breast cancer patients. c-erbB2 protein is an important antigen for tumor specific cytotoxic T lymphocytes induction that is dependent on its presentation as stably complexed with HLA-A2. In 1997, Nistico P reported low frequency of c-erbB2 proto-oncogene overexpression in HLA A2 positive breast cancer patients. And then in this study, correlation of HLA-A2 and the c-erbB2 expression was investigated in breast cancer patients. Materials and Methods: HLA-A DNA typing by locus-specific generic PCR and by hybridization with sequence-specific oligonucleotide probes (SSOP) was performed on peripheral blood lymphocytes from 52 breast cancer patients (a PCR-SSOP typing method, involving a PCR amplification in conjunction with digoxigenin labelled sequence-specific oligonucleotide probes). To determine c-erbB2 expression, immunohistochemistry from paraffin-embedded tissues in a series of 47 patients with available tissue blocks was performed by use of rabbit anti-human c-erbB2 oncoprotein (DAKO, Glostrup, Denmark). And then we statistically analyzed the relation between the expressions of HLA-A2 and c-erbB2 in breast cancer patients. Results: 29 out of 52 patients (55.8%) were HLA-A2 positive. 23.4% (11out of 47 patients) of breast cancer patients overexpressed c-erbB2. The patients with c-erbB2 overexpression showed lower estrogen receptor positivity compared to those without c-erbB2 overexpression (10.5%, vs 33.3%). HLA-A2 positive patients showed 18.5% (5/27) of overexpression and HLA-A2 negative patients showed 30.0% (6/20) of c-erbB2 overexpression (p=0.283). Conclusions: We observed no correlation between HLA-A2 and prognostic factors in breast cancer such as tumor size, axillary nodal status. However, our results showed a tendency without statistical significance between HLA-A2 and high frequency of c-erbB2 overexpression. More accumulation of patients will be needed for better conclusions.-
dc.description.statementOfResponsibilityopen-
dc.publisher한국유방암학회-
dc.relation.isPartOfJournal of Korean Breast Cancer Society (한국유방암학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title유방암 환자에서 HLA-A2와 c-erbB2의 발현-
dc.title.alternativeExpression of c-erbB2 and HLA-A2 in Breast Cancer Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthor이희대-
dc.contributor.googleauthor김도일-
dc.contributor.googleauthor정우희-
dc.contributor.googleauthor장윤수-
dc.contributor.googleauthor박전한-
dc.contributor.googleauthor구자윤-
dc.contributor.localIdA01641-
dc.contributor.localIdA03671-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ01504-
dc.subject.keywordBreast cancer-
dc.subject.keywordc-erbB2-
dc.subject.keywordHLA-A2-
dc.contributor.alternativeNamePark, Jeon Han-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor정우희-
dc.contributor.affiliatedAuthor정우희-
dc.citation.volume2-
dc.citation.number2-
dc.citation.startPage152-
dc.citation.endPage158-
dc.identifier.bibliographicCitationJournal of Korean Breast Cancer Society (한국유방암학회지), Vol.2(2) : 152-158, 1999-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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