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유방암 환자에서 HLA-A2와 c-erbB2의 발현
DC Field | Value | Language |
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dc.contributor.author | 박전한 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2020-01-23T05:29:58Z | - |
dc.date.available | 2020-01-23T05:29:58Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1598-3641 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174335 | - |
dc.description.abstract | Purpose: Oncogene c-erbB2 produces a transmembrane protein similar in structure to the tyrosine kinase family. Overexpression of c-erbB2 is known to lower the survival rate of breast cancer patients. c-erbB2 protein is an important antigen for tumor specific cytotoxic T lymphocytes induction that is dependent on its presentation as stably complexed with HLA-A2. In 1997, Nistico P reported low frequency of c-erbB2 proto-oncogene overexpression in HLA A2 positive breast cancer patients. And then in this study, correlation of HLA-A2 and the c-erbB2 expression was investigated in breast cancer patients. Materials and Methods: HLA-A DNA typing by locus-specific generic PCR and by hybridization with sequence-specific oligonucleotide probes (SSOP) was performed on peripheral blood lymphocytes from 52 breast cancer patients (a PCR-SSOP typing method, involving a PCR amplification in conjunction with digoxigenin labelled sequence-specific oligonucleotide probes). To determine c-erbB2 expression, immunohistochemistry from paraffin-embedded tissues in a series of 47 patients with available tissue blocks was performed by use of rabbit anti-human c-erbB2 oncoprotein (DAKO, Glostrup, Denmark). And then we statistically analyzed the relation between the expressions of HLA-A2 and c-erbB2 in breast cancer patients. Results: 29 out of 52 patients (55.8%) were HLA-A2 positive. 23.4% (11out of 47 patients) of breast cancer patients overexpressed c-erbB2. The patients with c-erbB2 overexpression showed lower estrogen receptor positivity compared to those without c-erbB2 overexpression (10.5%, vs 33.3%). HLA-A2 positive patients showed 18.5% (5/27) of overexpression and HLA-A2 negative patients showed 30.0% (6/20) of c-erbB2 overexpression (p=0.283). Conclusions: We observed no correlation between HLA-A2 and prognostic factors in breast cancer such as tumor size, axillary nodal status. However, our results showed a tendency without statistical significance between HLA-A2 and high frequency of c-erbB2 overexpression. More accumulation of patients will be needed for better conclusions. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | 한국유방암학회 | - |
dc.relation.isPartOf | Journal of Korean Breast Cancer Society (한국유방암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암 환자에서 HLA-A2와 c-erbB2의 발현 | - |
dc.title.alternative | Expression of c-erbB2 and HLA-A2 in Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 이희대 | - |
dc.contributor.googleauthor | 김도일 | - |
dc.contributor.googleauthor | 정우희 | - |
dc.contributor.googleauthor | 장윤수 | - |
dc.contributor.googleauthor | 박전한 | - |
dc.contributor.googleauthor | 구자윤 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01504 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | c-erbB2 | - |
dc.subject.keyword | HLA-A2 | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.contributor.affiliatedAuthor | 정우희 | - |
dc.citation.volume | 2 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 152 | - |
dc.citation.endPage | 158 | - |
dc.identifier.bibliographicCitation | Journal of Korean Breast Cancer Society (한국유방암학회지), Vol.2(2) : 152-158, 1999 | - |
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