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Significance of major histocompatibility complex(MHC) haplotype in the development of Behcet's disease-like symptom induced by herpes simplex virus in several inbred mouse strains

Other Titles
 몇가지 근교배 마우스에서 단순포진바이러스로 유발한 배체트병 발생과 MHC haplotype의 관련성 
 Seong-Hyang Sohn  ;  Eun-So Lee  ;  Dong-Sik Bang  ;  Sung-Nack Lee 
 Korean Journal of Laboratory Animal Science (한국실험동물학회지), Vol.15(1) : 61-66, 1999 
Journal Title
 Korean Journal of Laboratory Animal Science (한국실험동물학회지) 
Issue Date
It has been postulated that human leukocyte antigen (HLA)-B51 is associated with Behcet's disease. We already induced Behcet's disease-like symptom in ICR mice inoculated with herpes simplex virus. In order to demonstrate the role of histocompatibility antigen in the development of Behcet's diseaselike symptom, several inbred mouse strains-B10.BR (H-2 k 2k ), B10.RⅢ (H-2 r 2r ), Cb7BL/6 (H-2 b 2b ), C3H/He (H-2 k 2k )which had different types of major histocompatibility complex (MHC), were inoculated with herpes simplex virus type 1 (KOS strain). Manifestations such as oral, genital, cutaneous ulcers, uveitis, and arthritis, that are considered clinically significant for the diagnosis of Behcet's disease in patients appeared. By hematoxylin & eosin stain, inflammatory cells were accumulated around blood vessels in manifested skin tissues. HSV DNA was detected by polymerase chain reaction in skin lesions of B10.BR, B10.RⅢ and C57BL/6 strains. Behcet's disease-like symptoms were developed in 40∼50% of B10.BR, B10.RⅢ and C57BL/6 strains, but in only 2% of C3H/He. B10.BR and C3H/He strains had a common haplotype (H-2 k 2k ) but the rate of manifestation was different. So, these results indicate that MHC is not directly correlated with the development of Behcet's disease in the herpes simplex virus induced animal models.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
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