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소아 연령에 따른 IgG 및 IgG Subclass 정상치의 변화

Other Titles
 Normal Values of IgG and IgG Subclass Concentrations According to Age in Children 
 이연경  ;  김동수  ;  이기영  ;  이정운  ;  임형복 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.9(1) : 93-99, 1999 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
Issue Date
IgG ; IgG subclasses ; Nephelometry ; Children ; IgG subclass
Purpose : Currently the most widely used method of measuring IgG concentration is the method employing ELISA. This method has an advantage to detect smaller quantities than other standard methods, but in certain cases, consistent results cannot be obtained, thus impairing reliable data analysis. In this study, we attempt to determine the advantages in data analysis offered by the new method developed by Binding Site Ltd.(England) that employs a nephelometry. Methods : 20 healthy subjects were studied from each of the following age groups : neonates, 1-4 months old, 5-10 months old, 11-24 months old, and 2-5 years old children. Serum IgG and IgG subclass concentrations were measured by nephelometry(Gehring Nephelometer Analyzer Ⅱ, Germany) using Human IgG subclass, Liquid reagents BNⅡ kit(Binding Site Ltd., England). Results:1) The r values for the standard curves of IgG, IgG_1, IgG_2, IgG_3, IgG_4 concentrations were 0.991, 0.997, 0.980, 0.973, 0.997, respectively. 2) IgG, IgG_3, and IgG_4 concentrations were lowest at the age of 5-10 months and increased to normal adult levels at 2-5 years of age. 3) IgG_1 and IgG_2 were lowest at the age of 1-4 months and increased to normal adult levels at 2-5 years of age. Conclusion : The method employing nephelometry for measuring serum IgG & IgG subclasses concentration is not as sensitive as ELISA in detecting the lower concentrations. However, our studies indicate that it presents the advantage of better quality control in measuring values in the average range.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
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