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유방 엽상종양의 예후추정 인자로서의 DNA 배수성 분석

Other Titles
 DNA Ploidy Analysis as a Prognostic Indicator in Phyllodes Tumor of the Breast 
 김희정  ;  한재호  ;  정우희  ;  이희대 
 Korean Journal of Pathology (대한병리학회지), Vol.33(7) : 507-716, 1999 
Journal Title
 Korean Journal of Pathology (대한병리학회지) 
Issue Date
Breast ; Neoplasm ; Phyllodes tumor ; DNA ploidy ; Flow cytometry ; Prognosis
DNA ploidy analysis using flow cytometry was performed on sixty six cases of phyllodes tumor of the breast including benign, low grade and high grade malignant phyllodes tumor. The rate of aneuploidy was 41.2% in high grade malignant phyllodes tumor and 4.8% in benign phyllodes tumor. No aneuploidy was noted in low grade malignant phyllodes tumor. The recurrence rate according to DNA ploidy pattern revealed 16.7% of aneuploidy and 7.7% of diploidy. In the aneuploid cases, the DNA index of high grade malignant phyllodes tumor was higher than benign phyllodes tumor. Morever, in diploid cases, %SG2M were significantly higher in high grade malignant phyllodes tumor. Therefore, we conclude that DNA ploidy analysis as well as histologic characteristics such as cellularity, pleomorphism of stromal cells and mitoses is useful parameters in the diagnosis, recurrence and prognostic predictors of phyllodes tumor.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Jung, Woo Hee(정우희)
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