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Risk factors influencing the decline of residual renal function in continuous ambulatory peritoneal dialysis patients

 SK Shin  ;  H Noh  ;  SW Kang  ;  BJ Seo  ;  IH Lee  ;  HY Song  ;  KH Choi  ;  SK Ha  ;  HY Lee  ;  DS Han 
 Peritoneal Dialysis International, Vol.19(2) : 138-142, 1999 
Journal Title
 Peritoneal Dialysis International 
Issue Date
Female ; Humans ; Kidney/physiopathology* ; Kidney Failure, Chronic/physiopathology* ; Kidney Failure, Chronic/therapy ; Kidney Function Tests ; Linear Models ; Male ; Middle Aged ; Peritoneal Dialysis, Continuous Ambulatory* ; Peritonitis/epidemiology ; Retrospective Studies ; Risk Factors ; Time Factors
OBJECTIVE: To assess the nature of the decline in residual renal function (RRF) after the initiation of peritoneal dialysis, and to identify risk factors influencing the preservation of RRF. DESIGN: A retrospective single-center study. SETTING: Tertiary medical center. PATIENTS: Eighty patients who were clinically stable and had been on continuous ambulatory peritoneal dialysis (CAPD) for a minimum of 6 months. MAIN OUTCOME MEASURES: All subjects had at least three measurements of RRF, which was calculated as the average of creatinine clearance (Ccr) and urea clearance from a 24-hour urine collection. All measurements of RRF were plotted on a logarithmic scale and a linear scale against the duration of CAPD. Covariables used in the correlation analyses were age, sex, the presence of diabetes mellitus, mean blood pressure, mean diastolic blood pressure, hematocrit and Ccr at the start of peritoneal dialysis, peritoneal membrane transport characteristics by peritoneal equilibration test (PET), and the rate of peritonitis. RESULTS: A significant correlation was found between CAPD duration and RRF decline represented on a logarithmic scale with a correlation coefficient (r) of 0.355 (p < 0.001). In contrast, on a linear scale, the correlation coefficient was only 0.273 (p < 0.01). By linear multiple regression analysis, the only independent risk factor for the decline of RRF was the rate of peritonitis (r = -0.446, p < 0.001). CONCLUSION: These results suggest that RRF declines exponentially rather than linearly with time, and that the rate of peritonitis is an independent risk factor for the decline of RRF in CAPD patients.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
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