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아스피린 유발성 천식 환자에서 leukotriene C4(LTC4) 합성효소 유전자 다형에 관한 연구

Other Titles
 Leukotriene C4 synthase promoter polymorphism in aspirin-induced asthma 
Authors
 조재연  ;  이상엽  ;  한선애  ;  유세화  ;  김선신  ;  박해심  ;  박중원  ;  홍천수  ;  인광호 
Citation
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.19(4) : 542-547, 1999 
Journal Title
 Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) 
ISSN
 1226-8739 
Issue Date
1999
Keywords
LTC4 synthase ; polymorphism ; aspirin induced asthma ; LTC4 synthase
Abstract
Background: Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in their bronchial mucosa, compared to aspi- rin-tolerant asthma. Objective : We observed whether genetic polymorphism of LTC4 synthase may be predisposed to LTC4 synthase overexpression in AIA. Subject and method: Forty - four AIA patients having positive responses on lysin aspirin bron choprovocation tests and 47 non - aspirin induced asthma ( non - AIA ) patients having negative challenges and 32 healthy controls were enrolled. The genotypes of the promoter LTC4 synthase gene ( A,C transversion ) were determined by polymerase chain reaction and restriction frag- ment length polymorphism ( RFLP ) method. Results : LTC4 synthase promoter polymorphism ( A444C btransversion) was not significantly dif - ferent between non - AIA and AIA patients (p 〉0.05). Conclusion These findings suggest that genetic polymorphism of LTC4 synthase promoter may not be predisposed to LTC, synthase overexpression in AIA.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Hong, Chein Soo(홍천수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174146
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