0 156

Cited 0 times in

인간 자궁내막의 생리주기에 따른 성호르몬 수용체, integrin, cyclooxygenase(COX)의 발현 양상

Other Titles
 Expression Pattern of Sex Hormone Receptors, Integrins, Cyclooxygenases (COX) in Human Endometrium During Menstrual Cycle 
 양현원  ;  오기석  ;  김세광  ;  김영아  ;  주희재  ;  유희석  ;  권혁찬  ;  김진영  ;  이영돈  ;  조동제 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.42(3) : 614-621, 1999 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
cyclooxygenase(COX) ; estrogen수용체 ; progesterone수용체 ; Human Endometrium ; Estrogen ; receptor ; Progesterone receptor
OBJECTIVE: We examined the endometrium of women of reproductive age with
normal menstruation cycles to develop immunohistochemical indices that might
complement the histological classification suggested by Noyes et al.
STUDY DESIGN: Tissues were obtained firm the endometrium of the posterior fundus
in 42 women (proliferative phase-25 cases, secretory phase-17 cases) with normal
menstrual cycles(28-32days interval). The specimens were stained with H&E stain and
classified according to the method by Noyes et al(1950) into early proliferative phase(-5
∼-10days from ovulation), late proliferative phase(-4days∼ovulation), early secretory
phase (ovulation∼5days), mid-secretory phase(6∼10days from ovulation), and late
secretory posse(11-14days from ovulation). Immunohistochemical staining of integrin α1,
α4, β3, COX-1,-2, ER, PR expression was performed.
RESULT: The expression of ER was high in the proliferative phase and low during
the secretory phase. The late proliferative phase showed the highest intensity(p<0.05).
On the other hand, the expression of PR in stromal cells was relatively uniform during
the entire menstrual cycle. However, in epithelial cells, there was a characteristic peak
intensity in the late proliferative phase and low intensity in the secretory phase. The
expression of integrin α1, α4, β3 in epithelial cells showed no particular pattern in the
proliferative phase but showed specific findings in the secretory phase. In the epithelial
cells, the intensity of α1 staining was increased after the early proliferative phase and
sustained during the whole secretory phase(p<0.05), α4 was increased in the early and
mid-secretory phases, β3 was increased in the mid-secretory phase to late secretory
phase. But the stromal cells were weakly expressed in the whole menstrual cycle but
showed no particular pattern. In glandular epithelial cells and stromal cells, COX-1
showed a cyclic pattern according to menstrual cycle: it was strongly expressed in the
mid-secretory phase in glandular epithelial cells and mid-secretory and menstrual phase
in stromal cells(p<0.05). But in luminal epithelial cells, COX-1 was expressed in the
entire menstrual cycle but had no particular pattern. In glandular epithelial cells, stromal
cells, and luminal epithelial cells, COX-2 was not expressed during the secretly phase
but strongly expressed in the mid-secretory phase(p<0.05).
CONCLUSION: The expression of α1, α4, β3, and COX-2 showed as strong
staining during the mid secretory phase which represents the implantation period. The
PR expression in epithelial cells was decreased during same period. These characteristic
findings will provide helpful information for histological methods of endometrial dating
and will be useful in the measurement of endometrial maturation during the implantation
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sei Kwang(김세광)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.