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조기폐경 환자에서 조직학적 분석 및 Apoptosis관련 단백질 발현에 관한 연구

Other Titles
 Premature Ovarian Failure Histologic Analysis and Immunohistochemical Study of the Ovary with Apoptosis Related Proteins 
 박정식  ;  이병석  ;  정현용  ;  박기현  ;  이윤호  ;  조동제  ;  이국  ;  송찬호  ;  김재욱 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.42(12) : 2776-2781, 1999 
Journal Title
Korean Journal of Obstetrics and Gynecology(대한산부인과학회잡지)
Issue Date
Premature ovarian failure ; Apoptosis related protein
Objectives: Recently, it was suggested that apoptosis may be a basic mechanism of follicular atretic process. If the POF(premature ovarian failure) results from an acceleration of the process of atresia of the oocytes causing premature deletion of stored oocytes, POF may be a good model for the apoptosis. Our objective is to determine the relation between the POF and apoptosis. Methods: We performed laparoscopic ovarian biopsy in 17 patients with POF. We evaluated the ovaries from a patient with POF by conventional H-E stining and immunohistochemical staining for apoptosis related protein(bcl-2, bax, fas and fas-L). Results: Atretic cystic follicles were seen 4 out of 17 patients, and corpora albicans indicating past ovulation were seen 9 out of 17 patients. Primordial follicles were seen in 3 out of 17 patients, however developing follicles were not seen in all patients. Immunohistochemical analysis revealed that Bax was expressed in the lining cells of the atretic cystic follicle and primordial follicle and mesothelial cells lining the surface of the ovary. Fas and Fas-L were expressed on the lining pregranulosa cells and primary oocyte of the primordial follicle in the ovary of the patient with premature ovarian failure. Bax were also expressed on the lining pregranulosa cell and oocyte of the premature ovarian failure. Bcl-2 was expressed in the lining cells of primordial follicles of the patients with POF. Conclusion: Apoptosis may be a basic mechanism of POF. Bax, fas and fas-L may play a role causing premature follicular depletion.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
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