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Perfusion impairments in infantile autism on technetium-99m ethyl cysteinate dimer brain single-photon emission tomography: comparison with findings on magnetic resonance imaging

 Young Hoon Ryu  ;  Jong Doo Lee  ;  Pyeong Ho Yoon  ;  Dong Ik Kim  ;  Ho Bun Lee  ;  Yee Jin Shin 
 European Journal of Nuclear Medicine, Vol.26(3) : 253-259, 1999 
Journal Title
 European Journal of Nuclear Medicine 
Issue Date
Autistic Disorder/diagnostic imaging* ; Autistic Disorder/pathology ; Brain/diagnostic imaging* ; Brain/pathology ; Cerebrovascular Circulation ; Child, Preschool ; Cysteine/analogs & derivatives* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Organotechnetium Compounds* ; Radiopharmaceuticals ; Retrospective Studies ; Tomography, Emission-Computed, Single-Photon*
The neuro-anatomical substrate of autism has been the subject of detailed investigation. Because previous studies have not demonstrated consistent and specific neuro-imaging findings in autism and most such studies have been performed in adults and school-aged children, we performed a retrospective review in young children in search of common functional and anatomical abnormalities with brain single-photon emission tomography (SPET) using technetium-99m ethyl cysteinate dimer (ECD) and correlative magnetic resonance imaging (MRI). The patient population was composed of 23 children aged 28-92 months (mean: 54 months) who met the diagnostic criteria of autism as defined in the DSM-IV and CARS. Brain SPET was performed after intravenous injection of 185-370 MBq of 99mTc-ECD using a brain-dedicated annular crystal gamma camera. MRI was performed in all patients, including T1, T2 axial and T1 sagittal sequences. SPET data were assessed visually. Twenty patients had abnormal SPET scans revealing focal areas of decreased perfusion. Decreased perfusion of the cerebellar hemisphere (20/23), thalami (19/23), basal ganglia (5/23) and posterior parietal (10/23) and temporal (7/23) areas were noted on brain SPET. By contrast all patients had normal MRI findings without evidence of abnormalities of the cerebellar vermis, cerebellar hemisphere, thalami, basal ganglia or parietotemporal cortex. In conclusion, extensive perfusion impairments involving the cerebellum, thalami and parietal cortex were found in this study. SPET may be more sensitive in reflecting the pathophysiology of autism than MRI. However, further studies are necessary to determine the significance of thalamic and parietal perfusion impairment in autism.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
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