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Glucocorticoid가 토끼 음경해면체평활근에 미치는 영향

Other Titles
 Effect of Glucocorticoid on Rabbit Corpus Cavernosum Smooth Muscle 
 Korean Journal of Urology (대한비뇨기과학회지), Vol.40(2) : 234-239, 1999 
Journal Title
 Korean Journal of Urology (대한비뇨기과학회지) 
Issue Date
GLUCOCORTICOID ; 토끼 ; 음경해면체평활근 ; 마상열 ; 최형기 ; Cavernosal smooth muscle ; Rabbit
PURPOSE: Glucocorticoid contribute to the pathogenesis of hypertension through intracellular signals that stimulate vascular smooth muscle contraction. However, some in vitro and in vivo studies have shown that glucocorticoid has the potential role of vasorelaxation. Therefore, we tried to investigate the effect of short acting glucocorticoid (hydrocortisone; HCS) on the isolated rabbit cavernosal smooth muscle for evaluation of the possibility of using this material as a pharmacoerecting agent. MATERIALS AND METHODS: Strips of rabbit corpus cavernosum were mounted in organ chambers. On the precontracted muscle strips with phenylephrine(PHE; 5x10-6M), HCS was treated with increasing concentration from 10microgram/mL. The relaxing activity of ACh(10-7M), phentolamine(10-8M), papaverine(10-8M), verapamil(10-6M), PGE1(10-2M), SNAP(5x10-5M) were observed with the preparation of HCS. Depolarization by KCl were observed with HCS to investigate the relationship of HCS effects to K+. RESULTS: Pretreatment of muscle strips with low dose of HCS caused concentration-related increase of a PHE induced contraction. On muscle strips submaximally precontracted with PHE, HCS(10microgram/mL to 100microgram/mL) showed no relaxations. Pretreatment of muscle strips with 10microgram/mL dose of HCS caused a potentiation of a relaxation effects of ACh, papaverine, verapamil, SNAP, PGE1 and 50microgram/mL dose of HCS caused a potentiation of a relaxation effects of ACh, phentolamine. However, 100microgram/mL dose of HCS did not produce changes of these potentiating responses to relaxation. Also, HCS did not influenced the depolarization with any concentrations of KCl. CONCLUSIONS: HCS has the potentiating effect of both the PHE-induced contraction, and the relaxation of the ACh, phentolamine, papaverine, verapamil, SNAP, PGE1 at 10-50microgram/mL concentration on the cavernosal smooth muscle.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
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