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Expression of eosinophil chemotactic factors in stomach cancer

 Soon Won Hong  ;  Mee Yon Cho  ;  Chanil Park 
 Yonsei Medical Journal, Vol.40(2) : 131-136, 1999 
Journal Title
 Yonsei Medical Journal 
Issue Date
Cell Movement/physiology ; Chemotactic Factors, Eosinophil/metabolism* ; Eosinophils/physiology ; Humans ; Immunohistochemistry ; Mast Cells/physiology ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/physiopathology
We have occasionally experienced eosinophilic abscess of the liver in patients with gastric carcinoma, suggesting that some eosinophil mobilizing (chemotactic and proliferative) factors might be produced by carcinoma cells. The aim of this study was to determine whether or not gastric carcinoma expresses the well-known eosinophil chemotactic factors (ECFs) and whether or not the expression is related to the histologic subtypes. Seventeen consecutive surgically removed tumor-bearing stomachs were collected: 7 signet ring cell type, 7 poorly differentiated tubular adenocarcinoma, and 3 moderately differentiated tubular adenocarcinoma. Hematoxylin-eosin stained sections were re-evaluated for eosinophil and mast cell infiltration. The expression of IL-2, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF) were examined by immunocytochemical stain. There was no available frozen tissue for IL-2 and IL-5 in one case. Gastric carcinoma expressed IL-2 in all 16 cases, IL-5 in 12 of 16 cases and GM-CSF in 10 of 17 cases. Of particular interest, 7 of 10 GM-CSF-expressing carcinomas were signet ring cell type. Even in the remaining 3 cases, most GM-CSF-positive cells were signet ring cells scattered within tubular adenocarcinoma. No correlation of ECF expression between either eosinophil/mast cell infiltration or peripheral blood eosinophilia was identified. In conclusion, most gastric carcinomas express the well-known ECFs and the expression of GM-CSF is specific for signet ring carcinoma cells.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Chan Il(박찬일)
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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