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Cefatrizine/clavulanic acid의 주요 임상 분리주에 대한 시험관내 항균력

Other Titles
 In Vitro Activities of Cefatrizine/clavulanic Acid Against Major Clinical Isolates of Bacteria 
 정재림  ;  김영아  ;  신희봉  ;  신정원  ;  이경원  ;  정윤섭  ;  박장현  ;  김원배 
 대한임상미생물학회지(Korean Journal Of Clinical Microbiology), Vol.2(2) : 182-193, 1999 
Journal Title
 대한임상미생물학회지(Korean Journal Of Clinical Microbiology) 
Issue Date
Cefatrizine ; Cefatrizine/clavulanic acid ; Antimicrobial susceptibility
Background : β-lactam antibiotics are one of the most frequently used antimicrobial agents. However, with the increase of β-lactamase-producing bacteria, penicillins arid 1 st generation cephalosporins have become less useful. Cefatrizine and clavulanic acid combination (CTCA) was developed to restore the activity. The aim of this study was to determine the activities of CTCA against major recent clinical isolates. Methods : Aerobic and anaerobic bacteria tested were isolated from clinical specimens in Severance Hospital during 1996 to 1999. Antimicrobial susceptibility was determined by the NCCLS agar dilution methods. Results : MICs of cefatrizine (CT) and CTCA were similar for methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes and S. pneumoniae. For Moraxella (Branhamella) catarrhalis, MIC90 CTCA was 1 ㎍/mL, which was 1/8-fold lower than that of cefatrizine. MIC90S of CTCA for Escherichia coli and Klebsiella pneumoniae were 4 ㎍/mL and 8 ㎍/mL, respectively, which were 1/4- to 1/16-fold lower than those of CT. However, it was less active against Citrobacter freundii, Enterobacter cloacae and Serratia marcescens. Against Bacteroides fragilis group organisms, it showed good activities similar to those of other β-lactam and β -lactamase inhibitor combinations. Conclusions : CTCA showed good antimicrobial activities against M. (B.) catarrhalis, Haemophilus influenzae, Neisseria gonorrhoeae, extended spectrum β -lactamase-producing E. coli and K. pneumoniae, Proteus vulgaris and B. fragilis. In conclusion, it would be useful for the treatment of infections due to those organisms, and for the empirical treatment of respiratory and urinary tract infections.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
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