21 37

Cited 27 times in

Deletion mapping of chromosome 16q in hepatocellular carcinoma

Authors
 Z Piao  ;  C Park  ;  JJ Kim  ;  H Kim 
Citation
 Br J Cancer, Vol.80(5~6) : 850-854, 1999 
Journal Title
 Br J Cancer 
ISSN
 0007-0920 
Issue Date
1999
MeSH
Alleles ; Carcinoma, Hepatocellular/genetics* ; Chromosome Mapping* ; Chromosomes, Human, Pair 16* ; DNA, Neoplasm/genetics ; Gene Deletion* ; Genes, Tumor Suppressor ; Humans ; Liver Neoplasms/genetics* ; Loss of Heterozygosity ; Microsatellite Repeats
Abstract
Hepatocellular carcinoma (HCC) frequently shows an allelic imbalance (AI) on chromosome 16q. In order to define the commonly affected regions on chromosome 16q, we assessed AI studies in 41 HCCs using a panel of 37 microsatellite markers. Thirty-five cases (85%) showed AI at one or more loci. Among the 35 cases with AI, 21 cases showed multiple AI, suggesting the wide scope of deletion on the long arm of chromosome 16, and the remaining 14 cases showed partial AI. Detailed deletion mapping identified two independent commonly deleted regions on this chromosome arm. These included the D16S3106 locus and D16S498 locus. In conclusion, we have demonstrated frequent AI on 16q in HCCs and identified two loci with frequent AI, which may harbour new tumour suppressor genes.
Files in This Item:
T199902440.pdf Download
DOI
10.1038/sj.bjc.6690431
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
Park, Chan Il(박찬일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173763
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse