267 423

Cited 0 times in

Clinical outcomes and tear cytokine profiles of meibomian gland dysfunction treated with intense pulsed light

Other Titles
 마이봄샘 기능이상 환자에서 intense pulsed light의 임상적 효과 및 눈물내 사이토카인 분석 
Authors
 최문정 
College
 Graduate School, Yonsei University 
Department
 Dept. of Medicine 
Degree
석사
Issue Date
2017
Abstract
Objective: To analyse the alteration in tear cytokine profiles, clinical
outcome, and prognostic factors in meibomian gland dysfunction (MGD)
patients treated with Intense Pulsed Light (IPL).
Methods: Participants with moderate to severe MGD were treated with 3
sessions of IPL. Bimicroscopic examinations of meibomian glands and
lid margins, tear break-up time (TBUT), ocular surface staining,
interferometry, Ocular Surface Disease Index (OSDI), and tear cytokine
levels were evaluated.
Results: There was a significant improvement in clinical parameters
including meibum quality, meibum expressibility, lid margin abnormality,
TBUT, ocular surface staining, and OSDI. There was significant decrease
in IL-6 and TNF-α. The decrease in tear cytokine levels were correlated
with the improvement in clinical outcome (meibum quality, expressibility,
lid margin abnormality, and ocular surface staining). Worse meibum
expressibility, and low TBUT were associated with greater reduction in
OSDI after treatment.
Conclusions: IPL lead to decreased inflammation, improved meibomian
gland function, and ocular surface stabilization in MGD patients.
Improvement in meibomian expressibility was associated with the
significant reduction of inflammatory cytokines, IL-6 and TNF-α, and
baseline meibum nonexpressibility and low TBUT was associated with
decreased subjective symptom score after treatment. Therefore, patients
with obstructive MGD are especially likely to benefit from IPL
treatment.
Files in This Item:
TA02087.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 2. Thesis
Yonsei Authors
Choi, Moonjung(최문정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173624
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links