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In vivo efficacy of combination of colistin with fosfomycin or minocycline in a mouse model of multidrug-resistant Acinetobacter baumannii pneumonia

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dc.contributor.author구남수-
dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author신성재-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author용동은-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author최흔-
dc.date.accessioned2019-12-18T01:27:52Z-
dc.date.available2019-12-18T01:27:52Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173533-
dc.description.abstractUnfortunately, the options for treating multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections are extremely limited. Recently, fosfomycin and minocycline were newly introduced as a treatment option for MDR A. baumannii infection. Therefore, we investigated the efficacy of the combination of colistin with fosfomycin and minocycline, respectively, as therapeutic options in MDR A. baumannii pneumonia. We examined a carbapenem-resistant A. baumannii isolated from clinical specimens at Severance Hospital, Seoul, Korea. The effect of colistin with fosfomycin, and colistin with minocycline on the bacterial counts in lung tissue was investigated in a mouse model of pneumonia caused by MDR A. baumannii. In vivo, colistin with fosfomycin or minocycline significantly (p < 0.05) reduced the bacterial load in the lungs compared with the controls at 24 and 48 h. In the combination groups, the bacterial loads differed significantly (p < 0.05) from that with the more active antimicrobial alone. Moreover, the combination regimens of colistin with fosfomycin and colistin with minocycline showed bactericidal and synergistic effects compared with the more active antimicrobial alone at 24 and 48 h. This study demonstrated the synergistic effects of combination regimens of colistin with fosfomycin and minocycline, respectively, as therapeutic options in pneumonia caused by MDR A. baumannii.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIn vivo efficacy of combination of colistin with fosfomycin or minocycline in a mouse model of multidrug-resistant Acinetobacter baumannii pneumonia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSu-Hyung Lee-
dc.contributor.googleauthorYoung- soun Lim-
dc.contributor.googleauthorHeun Choi-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Hwa Choi-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1038/s41598-019-53714-0-
dc.contributor.localIdA00189-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA02114-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA02423-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04227-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid31748527-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김준명-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor신성재-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor용동은-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.contributor.affiliatedAuthor최흔-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPagee17127-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.9(1) : e17127, 2019-
dc.identifier.rimsid63529-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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